Dr. Antonio Migheli

Dr. Antonio Migheli

Specialista in Neurologia

Medico di Medicina Generale
Moncalieri (TO) | Vedi mappa
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Specialista in Neurologia
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Specialista in
Neurologia
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Dove ricevo
Studio medico privato
Studio medico privato
V Conte Cavour 19
10024 - Moncalieri (TO)
Studio medico privato
Studio medico privato
Via cavour 19
10024 - Moncalieri (TO)
Curriculum
Data e luogo di nascita: 27/7/1957 Perugia Email: amigheli@gmail.com Formazione 1982 Università di Torino Laurea in Medicina e Chirurgia 1986 Università di Torino Specializzazione in Neurologia 1988 MPI, Roma Dottorato di Ricerca in Scienze Neurologiche 1996 EURO-CNS, Parigi European Board of Neuropathology 2001 Professore Associato (idoneità) in Neuropatologia Esperienza professionale 1980-1985: Laboratorio di Neuropatologia, Dipartimento di Neuroscienze, Università di Torino 1985-1986: Research Fellow, Departments of Pathology and Pharmacology, New York University 1986-1991: Laboratorio di Neuropatologia, Dipartimento di Neuroscienze, Università di Torino 1991-1992: Visiting Assistant Professor, Department of Pathology, Columbia University 1992-2002 : Laboratorio di Neuropatologia, Dipartimento di Neuroscienze, Università di Torino 1994-2002: Docente a Contratto di Neuropatologia, Scuole di Specializzazione in Neurologia e Anatomia Patologica, Università di Torino. 2006- : Consulente di Neuropatologia, DOMP, Ospedale Maria Vittoria, Torino 1985-: Medico di Medicina Generale Convenzionato ASL TO5 -Moncalieri Direzione di Progetti di Ricerca 1993-1994: Telethon (“Role of heat shock proteins in amyotrophic lateral sclerosis”) 1994-1997: EC-Copernicus (“Molecular cell biology of cell stress proteins in health and disease”) 1996-1999: Telethon (“Motor neuron death in amyotrophic lateral sclerosis: The role of apoptosis”) 2000: Fondazione Cavalieri Ottolenghi ("Mechanisms and modulation of neuronal death following early cortical lesions in rat") 2000-2003: Responsabile di Unità Operativa di progetto multicentrico Ministero della Sanità ("Trapianti neurali e malattia di Alzheimer: studi preliminari ad un approccio terapeutico") 2000-2003: Coordinatore di progetto multicentrico Telethon ("Role of the ubiquitin/proteasome pathway in the degeneration of motor neurons in in vitro and in vivo models of familial amyotrophic lateral sclerosis") Affiliazioni a Società Scientifiche American Association of Neuropathologists (Active Member) Altre notizie di interesse scientifico Associate Editor della rivista Brain Pathology, organo ufficiale della International Society for Neuropathology Principali interessi di ricerca: Malattie neurodegenerative umane e modelli animali di neurodegenerazione. Pubblicazioni Autore di oltre 70 pubblicazioni in extenso su riviste censite da Medline. PRINCIPALI PUBBLICAZIONI 1. Migheli A, Butler M, Brown K, Shelanski ML. Light and electron microscope localization of the microtubule-associated tau protein in rat brain. J Neurosci 8:1846-1851, 1988. 2. Migheli A, Cavalla P, Marino S, Schiffer D. A study of apoptosis in normal and pathological nervous tissue after in situ end-labeling of DNA strand breaks. J Neuropathol Exp Neurol 53:606-616, 1994. 3. Yan SD, Chen X, Fu J, Chen M, Zxu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. RAGE and amyloid-ß peptide neurotoxicity in Alzheimer’s disease. Nature 382:685-691, 1996. 4. Migheli A, Piva R, Atzori C, Troost D, Schiffer D. c-Jun, JNK/SAPK kinases and transcription factor NF-kB are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 56:1314-1322, 1997. 5. Migheli A, Piva R, Wei J, Attanasio A, Casolino S, Dlouhy SR, Bayer SA, Ghetti B. Diverse cell death pathways result from a single missense mutation in weaver mouse. Am J Pathol 151:1629-1638, 1997. 6. Migheli A, Piva R, Casolino S, Atzori C, Dlouhy SR, Ghetti B. A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. Am J Pathol 155:365-373, 1999. 7. Migheli A, Atzori C, Piva R, Tortarolo M, Girelli M, Schiffer D, Bendotti C. Lack of apoptosis in mice with ALS. Nature Med 5:966-967, 1999. 8. Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, Ghetti B, Harris DA. Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation. Proc Natl Acad Sci USA 97:5574-5579, 2000. 9. Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron 28:115-127, 2000. 10. Atzori C, Ghetti B, Piva R, Srinivasan AN, Zolo P, Delisle MB, Mirra SS, Migheli A. Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J Neuropathol Exp Neurol 60:1190-1197, 2001. 11. Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 22:9340-51, 2002. 12. Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A. Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J Neuropathol Exp Neurol. 63:113-9, 2004. 13. Bigini P, Atzori C, Fumagalli E, Cagnotto A, Barbera S, Migheli A, Mennini T. Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse. Neurosci Lett. 426:106-10, 2007. 14. Imperiale D, Taraglio S, Atzori C, Testi R, Buffa C, Migheli A. Multifocal necrotizing leukoencephalopathy mimicking sporadic Creutzfeldt-Jakob disease. Eur Neurol, 59:327-9, 2008 15. Migheli A. EM-ISEL: a useful tool to visualize DNA damage at the ultrastructural level. Methods Mol Biol.  682:29-36, 2011 16. Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, et al. The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. PLoS One 6(7):e22370. Epub 2011 Jul 28, 2011 17. Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R. Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction. PLoS One PLoS One Apr 29; 6(4):e19339. Epub 2011 Apr 29, 2011