Dr. Enzo Bonmassar

Dr. Enzo Bonmassar

Specialista in Oncologia

Medico Ospedaliero
Prov. di Roma
follower
Specialista in
Oncologia
Curriculum
ENZO BONMASSAR MD, PhD CURRICULUM VITAE PERSONAL DATA Citizen: Italy Address: Via Fregene, 12 00183 Roma (Italy) Tel +39-3331824062 e-mail bonmasse@yahoo.com DEGREES AND SPECIAL COURSES 1956 - Graduated in Pharmacy at the University of Padova (Italy). 1966 - PhD - (Libera Docenza) Chemotherapy, Rome (Italy). 1967 - M.D., degree "cum laude", at the University of Pavia (Italy). 1968 - PhD - (Libera Docenza) Pharmacology, Rome (Italy). FELLOWSHIP RECEIVED 1963-1964 Fellowship of the Italian Government for Research in Tumor Immunopharmacology. 1967-1968 Fellowship of the Italian Government for Research in Tumor Immunopharmacology. 1968 IARC Travel Fellowship (W.H.O.). 1982 AIRC Fellowship. CURRENT MEMBERSHIP IN SCIENTIFIC SOCIETIES 1. American Association for Cancer Research. 2. American Society for Pharmacology and Experimental Therapeutics. 3. American Society for Clinical Pharmacology and Therapeutics. 4. American Association of Immunologists. 5 . Italian Society of Pharmacology. 6. Italian Society of Chemotherapy. POSITIONS HELD AND SCIENTIFIC ACTIVITY IN ITALY A. Academic positions 2008- present Contract Professor of Pharmacology, Department of Neuroscience, “Tor Vergata” University of Rome 1982-2008 Chairman of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, and more recently Department of Neuroscience, “Tor Vergata” University of Rome. 1984-2006 Director of the Postgraduate School of Oncology, “Tor Vergata” University of Rome. 1971-1981 Chairman of Pharmacology and Director of the Institute of Pharmacology, School of Medicine, University of Perugia 1970-1971 Associate Professor of Chemotherapy, School of Pharmacy, State University of Milano 1960-1971 Assistant Professor of Pharmacology, Institute of Pharmacology, School of Medicine, State University of Milan. .1956-1957 Research Associate at the Institute of Pharmacology, School of Medicine, State University of Milan. B. Scientific activity 2010-present Reasearch Associate at the Institute of Translational Pharmacology of the National Council of Research (CNR), Rome 1986-2010 Research Associate at the Institute of Neurobiology and Molecular Medicine of the National Council of Research (CNR), Rome 2009-2011 Research Associate at the Haemato-Oncology Department of the European Institute of Oncology (IEO), Milan 1995-2002 Member of the “WHO Melanoma Program” Committee 1991-1998 Member of the Committee of the Finalized Project of Clinical Application of Cancer Research (CNR, Rome). 1990-1998 Scientific Director of the PhD Course of Hematology, “Tor Vergata” University of Rome. 1984-1986 Director of the Institute of Experimental Medicine of the National Research Council (C.N.R.), Rome. 1984-1989 Responsible of the Pharmacology Section of the Finalized Project of Oncology of the National Research Council (C.N.R.), Italy. 1977-1983 Responsible of the Section of Cancer Chemotherapy of the Finalized Project of the Control of Neoplastic Growth of the National Council of Research (C.N.R.), Rome.. 1957-1960 Research Associate and Later Chief of the Section of Pharmaceutical Techniques of the Research Department, Glaxo Laboratories, Verona . POSITIONS HELD AND SCIENTIFIC ACTIVITY IN USA A. Permanent positions 1974-1975 Head of the Immunochemotherapy Section, Laboratory of Experimental Chemotherapy, DR&D, DCT, National Cancer Institute, National Institutes of Health, Bethesda, Md. 1973 Acting Head of the Immunochemotherapy Section, Laboratory of Experimental Chemotherapy, DR&D, DCT, National Cancer Institute, National Institutes of Health, Bethesda, Md. B. Scientific activity 2003-2004 Guest worker at the Laboratory of Prof. Carlo Croce, Kimmel Cancer Center (Jefferson Medical college, Thomas Jefferson University, Philadelphia, Pa) 1993 Guest worker at the Laboratory of Tumor Immunology and Biology (Dr J Schlom) of the National Cancer Institute, National Institutes of Health, Bethesda, Md 1982-1983 Guest worker at the Laboratory of Tumor Cell Biology (Dr. R.C. Gallo) of the National Cancer Institute, National Institutes of Health, Bethesda 1969-1970 Visiting Scientist (1969-70) Cancer Chemotherapy Department, Microbiological Associates Inc., Bethesda, Md. ENZO BONMASSAR full papers 1: Aquino A, Graziani G, Franzese O, Prete SP, Bonmassar E, Bonmassar L, D'Atri S. Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes. Clin Dev Immunol. 2011;2011:790460. Epub 2011 Mar 22. Review. PubMed PMID: 21603161; PubMed Central PMCID: PMC3095450. 2: Levati L, Pagani E, Romani S, Castiglia D, Piccinni E, Covaciu C, Caporaso P, Bondanza S, Antonetti FR, Bonmassar E, Martelli F, Alvino E, D'Atri S. MicroRNA-155 targets the SKI gene in human melanoma cell lines. Pigment Cell Melanoma Res. 2011 Jun;24(3):538-50. doi: 10.1111/j.1755-148X.2011.00857.x. Epub 2011 May 5. PubMed PMID: 21466664. 3: Bonmassar L, Fossile E, Scoppola A, Graziani G, Prete SP, Formica V, Cappelletti D, De Vecchis L, Cardillo A, Concolino F, D'Atri S, Balduzzi A, Torino F, Caporaso P, Greiner JW, Bonmassar E, Roselli M, Aquino A. Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies. Anticancer Res. 2010 Nov;30(11):4721-30. PubMed PMID: 21115931. 4: Barillari G, Franzese O, Comandini A, Bonmassar E, Ensoli B. Spindle cells from AIDS-associated Kaposi's sarcoma lesions express telomerase activity that is enhanced by Kaposi's sarcoma progression factors. Oncol Rep. 2010 Jul;24(1):219-23. PubMed PMID: 20514465. 5: Caporali S, Alvino E, Starace G, Ciomei M, Brasca MG, Levati L, Garbin A, Castiglia D, Covaciu C, Bonmassar E, D'Atri S. The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound. Pharmacol Res. 2010 May;61(5):437-48. Epub 2009 Dec 21. PubMed PMID: 20026273. 6: Forte G, Franzese O, Pagliari S, Pagliari F, Di Francesco AM, Cossa P, Laudisi A, Fiaccavento R, Minieri M, Bonmassar E, Di Nardo P. Interfacing Sca-1(pos) mesenchymal stem cells with biocompatible scaffolds with different chemical composition and geometry. J Biomed Biotechnol. 2009;2009:910610. Epub 2009 Jul 21. PubMed PMID: 19644551; PubMed Central PMCID: PMC2715823. 7: Levati L, Alvino E, Pagani E, Arcelli D, Caporaso P, Bondanza S, Di Leva G, Ferracin M, Volinia S, Bonmassar E, Croce CM, D'Atri S. Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155. Int J Oncol. 2009 Aug;35(2):393-400. PubMed PMID: 19578755. 8: Faraoni I, Antonetti FR, Cardone J, Bonmassar E. miR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta. 2009 Jun;1792(6):497-505. Epub 2009 Mar 5. Review. PubMed PMID: 19268705. 9: Caporali S, Levati L, Starace G, Ragone G, Bonmassar E, Alvino E, D'Atri S. AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. Mol Pharmacol. 2008 Jul;74(1):173-83. Epub 2008 Apr 15. PubMed PMID: 18413665. 10: Castiglia D, Bernardini S, Alvino E, Pagani E, De Luca N, Falcinelli S, Pacchiarotti A, Bonmassar E, Zambruno G, D'Atri S. Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. Genes Chromosomes Cancer. 2008 Jul;47(7):614-24. PubMed PMID: 18384130. 11: Rossi L, Bonmassar E, Faraoni I. Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. Pharmacol Res. 2007 Sep;56(3):248-53. Epub 2007 Jul 10. PubMed PMID: 17702597. 12: Caporaso P, Turriziani M, Venditti A, Marchesi F, Buccisano F, Tirindelli MC, Alvino E, Garbin A, Tortorelli G, Toppo L, Bonmassar E, D'Atri S, Amadori S. Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia. DNA Repair (Amst). 2007 Aug 1;6(8):1179-86. Epub 2007 May 17. PubMed PMID: 17500047. 13: Franzese O, Adamo R, Pollicita M, Comandini A, Laudisi A, Perno CF, Aquaro S, Bonmassar E. Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4(+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1). J Med Virol. 2007 May;79(5):639-46. PubMed PMID: 17387751. 14: De Rossi A, Rossi L, Laudisi A, Sini V, Toppo L, Marchesi F, Tortorelli G, Leti M, Turriziani M, Aquino A, Bonmassar E, De Vecchis L, Torino F. Focus on Fotemustine. J Exp Clin Cancer Res. 2006 Dec;25(4):461-8. Review. PubMed PMID: 17310834. 15: Pagani E, Falcinelli S, Pepponi R, Turriziani M, Caporaso P, Caporali S, Bonmassar E, D'Atri S. Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity. Int J Oncol. 2007 Feb;30(2):443-51. PubMed PMID: 17203227. 16: Alvino E, Castiglia D, Caporali S, Pepponi R, Caporaso P, Lacal PM, Marra G, Fischer F, Zambruno G, Bonmassar E, Jiricny J, D'Atri S. A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system. Int J Oncol. 2006 Oct;29(4):785-97. PubMed PMID: 16964376. 17: Fuggetta MP, Lanzilli G, Tricarico M, Cottarelli A, Falchetti R, Ravagnan G, Bonmassar E. Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro. J Exp Clin Cancer Res. 2006 Jun;25(2):189-93. PubMed PMID: 16918129. 18: Di Pucchio T, Pilla L, Capone I, Ferrantini M, Montefiore E, Urbani F, Patuzzo R, Pennacchioli E, Santinami M, Cova A, Sovena G, Arienti F, Lombardo C, Lombardi A, Caporaso P, D'Atri S, Marchetti P, Bonmassar E, Parmiani G, Belardelli F, Rivoltini L. Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. Cancer Res. 2006 May 1;66(9):4943-51. PubMed PMID: 16651452. 19: Correale P, Cusi MG, Micheli L, Nencini C, Del Vecchio MT, Torino F, Aquino A, Bonmassar E, Francini G, Giorgi G. Chemo-immunotherapy of colorectal carcinoma: preclinical rationale and clinical experience. Invest New Drugs. 2006 Mar;24(2):99-110. Review. PubMed PMID: 16502353. 20: Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Int J Oncol. 2006 Mar;28(3):641-8. PubMed PMID: 16465368. 21: Turriziani M, Caporaso P, Bonmassar L, Buccisano F, Amadori S, Venditti A, Cantonetti M, D'Atri S, Bonmassar E. O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro. Pharmacol Res. 2006 Apr;53(4):317-23. Epub 2006 Jan 10. PubMed PMID: 16412662. 22: Correale P, Del Vecchio MT, Di Genova G, Savellini GG, La Placa M, Terrosi C, Vestri M, Urso R, Lemonnier F, Aquino A, Bonmassar E, Giorgi G, Francini G, Cusi MG. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst. 2005 Oct 5;97(19):1437-45. PubMed PMID: 16204693. 23: Faraoni I, Cottarelli A, Giuliani A, Bonmassar L, Rossi L, Bonmassar E. A novel telomerase-based approach to detect natural cell-mediated cytotoxic activity against tumor cells in vitro. J Immunol Methods. 2005 Oct 30;305(2):162-72. Epub 2005 Aug 16. PubMed PMID: 16165149. 24: Correale P, Cusi MG, Tsang KY, Del Vecchio MT, Marsili S, Placa ML, Intrivici C, Aquino A, Micheli L, Nencini C, Ferrari F, Giorgi G, Bonmassar E, Francini G. Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J Clin Oncol. 2005 Dec 10;23(35):8950-8. Epub 2005 Aug 1. PubMed PMID: 16061910. 25: Correale P, Cusi MG, Del Vecchio MT, Aquino A, Prete SP, Tsang KY, Micheli L, Nencini C, La Placa M, Montagnani F, Terrosi C, Caraglia M, Formica V, Giorgi G, Bonmassar E, Francini G. Dendritic cell-mediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response with antitumor activity in vitro. J Immunol. 2005 Jul 15;175(2):820-8. Erratum in: J Immunol. 2005 Nov 1;175(9):6235. Prete, Salvatore [corrected to Prete, Salvatore Pasquale]. PubMed PMID: 16002679. 26: Prete SP, Rossi L, Correale PP, Turriziani M, Baier S, Tamburrelli G, De Vecchis L, Bonmassar E, Aquino A. Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells. Pharmacol Res. 2005 Aug;52(2):167-73. PubMed PMID: 15967383. 27: Tricarico M, Nunziata C, Atzori F, Concolino F, Macchini V, D'Atri S, Prete SP, Turriziani M, Lanzilli G, Sera F, Abeni D, Albanesi V, Bonmassar E, Pagani E. Adjuvant therapy of melanoma patients (stage II, III): a pilot immuno-toxicological study. J Exp Clin Cancer Res. 2004 Dec;23(4):573-8. PubMed PMID: 15743026. 28: Bruno E, Bonmassar E, Di Girolamo S, Adamo R, Alessandrini M, Ottaviani F, Rosati F, Franzese O. Evaluation of telomerase activity in nasal polyps. Am J Rhinol. 2004 Jul-Aug;18(4):197-201. PubMed PMID: 15490565. 29: Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Mol Pharmacol. 2004 Sep;66(3):478-91. PubMed PMID: 15322239. 30: Franzese O, Comandini A, Adamo R, Sgadari C, Ensoli B, Bonmassar E. HIV-Tat down-regulates telomerase activity in the nucleus of human CD4+ T cells. Cell Death Differ. 2004 Jul;11(7):782-4. PubMed PMID: 15017382. 31: Aquino A, Formica V, Prete SP, Correale PP, Massara MC, Turriziani M, De Vecchis L, Bonmassar E. Drug-induced increase of carcinoembryonic antigen expression in cancer cells. Pharmacol Res. 2004 May;49(5):383-96. Review. PubMed PMID: 14998548. 32: Turriziani M, Di Giacomo AM, Cardillo A, Torino F, Tentori L, Nasuti P, Massara MC, Roselli M, Bonmassar E, De Vecchis L. Residual telomerase activity: a marker of cell survival after exposure to gamma radiation in vitro. Anticancer Res. 2003 Nov-Dec;23(6C):4561-9. PubMed PMID: 14981897. 33: Roscetti G, Franzese O, Comandini A, Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin. Phytother Res. 2004 Jan;18(1):66-72. PubMed PMID: 14750204. 34: Correale P, Aquino A, Giuliani A, Pellegrini M, Micheli L, Cusi MG, Nencini C, Petrioli R, Prete SP, De Vecchis L, Turriziani M, Giorgi G, Bonmassar E, Francini G. Treatment of colon and breast carcinoma cells with 5-fluorouracil enhances expression of carcinoembryonic antigen and susceptibility to HLA-A(*)02.01 restricted, CEA-peptide-specific cytotoxic T cells in vitro. Int J Cancer. 2003 Apr 20;104(4):437-45. Erratum in: Int J Cancer. 2003 Jul 20;105(6):882. PubMed PMID: 12584740. 35: Pepponi R, Marra G, Fuggetta MP, Falcinelli S, Pagani E, Bonmassar E, Jiricny J, D'Atri S. The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. J Pharmacol Exp Ther. 2003 Feb;304(2):661-8. PubMed PMID: 12538819. 36: Sigala S, Tognazzi N, Rizzetti MC, Faraoni I, Missale C, Bonmassar E, Spano P. Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145. Eur J Endocrinol. 2002 Sep;147(3):407-15. PubMed PMID: 12213679. 37: Aquino A, Prete SP, Balduzzi A, Formica V, Fossile E, Bonmassar L, Concolino F, Bonmassar E, Graziani G. Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells. Int J Cancer. 2002 Jul 1;100(1):119-21. PubMed PMID: 12115597. 38: Prete SP, Cappelletti D, Baier S, Nasuti P, Guadagni F, De Vecchis L, Greiner JW, Bonmassar E, Graziani G, Aquino A. Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine. Int Immunopharmacol. 2002 Apr;2(5):641-51. PubMed PMID: 12013504. 39: Tentori L, Leonetti C, Scarsella M, d'Amati G, Portarena I, Zupi G, Bonmassar E, Graziani G. Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99(6):2241-4. PubMed PMID: 40: Franzese O, Balestrieri E, Comandini A, Forte G, Macchi B, Bonmassar E. Telomerase activity of human peripheral blood mononuclear cells in the course of HTLV type 1 infection in vitro. AIDS Res Hum Retroviruses. 2002 Mar 1;18(4):249-51. PubMed PMID: 11860671. 41: Alvino E, Marra G, Pagani E, Falcinelli S, Pepponi R, Perrera C, Haider R, Castiglia D, Ferranti G, Bonmassar E, Jiricny J, Zambruno G, D'Atri S. High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma. J Invest Dermatol. 2002 Jan;118(1):79-86. PubMed PMID: 11851879. 42: Giuliani A, Prete SP, Graziani G, Aquino A, Balduzzi A, Sugita M, Brenner MB, Iona E, Fattorini L, Orefici G, Porcelli SA, Bonmassar E. Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells. Infect Immun. 2001 Dec;69(12):7461-70. PubMed PMID: 11705921; PubMed Central PMCID: PMC98835. 43: Comandini FA, Lombardi A, Saponiero A, Bonmassar E. Saquinavir up-regulates telomerase activity in lymphocytes activated with monoclonal antibodies against CD3/CD28. J Chemother. 2001 Aug;13(4):384-8. PubMed PMID: 11589480. 44: Franzese O, Lombardi A, Comandini A, Cannavò E, Testorelli C, Cirello I, Bonmassar E. Effect of Saquinavir on proliferation and telomerase activity of human peripheral blood mononuclear cells. Life Sci. 2001 Aug 17;69(13):1509-20. PubMed PMID: 11554612. 45: Tentori L, Balduzzi A, Portarena I, Levati L, Vernole P, Gold B, Bonmassar E, Graziani G. Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester. Cell Death Differ. 2001 Aug;8(8):817-28. PubMed PMID: 11526435. 46: Faraoni I, Bonmassar E, Graziani G. Clinical applications of telomerase in cancer treatment. Drug Resist Updat. 2000 Jun;3(3):161-170. PubMed PMID: 11498381. 47: Pepponi R, Graziani G, Falcinelli S, Vernole P, Levati L, Lacal PM, Pagani E, Bonmassar E, Jiricny J, D'Atri S. hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis. 2001 Aug;22(8):1131-7. PubMed PMID: 11470740. 48: Tentori L, Portarena I, Bonmassar E, Graziani G. Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. Cell Death Differ. 2001 May;8(5):457-69. PubMed PMID: 11423906. 49: Periti P, Romani L, Bonmassar E, Puccetti P. Drugs and the immune system: the emerging era of immunopharmacology. Trends Immunol. 2001 Apr;22(4):178-80. PubMed PMID: 11394350. 50: Tentori L, Portarena I, Vernole P, De Fabritiis P, Madaio R, Balduzzi A, Roy R, Bonmassar E, Graziani G. Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components. Cancer Chemother Pharmacol. 2001 Apr;47(4):361-9. PubMed PMID: 11345654. 51: Cappelletti D, Cardillo A, Bonanno E, Prete SP, Cucchiara G, Turriziani M, Greiner JW, Cottarelli A, Breda E, Aquino A, Bonmassar E, De Vecchis L. Drug-induced modulation of carcinoembryonic antigen (CEA) expression in neoplastic cells from a patient with rectal cancer. J Exp Clin Cancer Res. 2000 Dec;19(4):467-9. PubMed PMID: 11277324. 52: Prete SP, Giuliani A, Iona E, Fattorini L, Orefici G, Franzese O, Bonmassar E, Graziani G. Bacillus Calmette-Guerin down-regulates CD1b induction by granulocyte-macrophage colony stimulating factor in human peripheral blood monocytes. J Chemother. 2001 Feb;13(1):52-8. PubMed PMID: 11233801. 53: Aquino A, Prete SP, Guadagni F, Greiner JW, Giuliani A, Orlando L, Masci G, De Santis S, Bonmassar E, Graziani G. Effect of 5-fluorouracil on carcinoembryonic antigen expression and shedding at clonal level in colon cancer cells. Anticancer Res. 2000 Sep- Oct;20(5B):3475-84. PubMed PMID: 11131650. 54: Tentori L, Vernole P, Lacal PM, Madaio R, Portarena I, Levati L, Balduzzi A, Turriziani M, Dande P, Gold B, Bonmassar E, Graziani G. Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells. Leukemia. 2000 Aug;14(8):1451-9. PubMed PMID: 10942242. 55: Fuggetta MP, Alvino E, Tricarico M, D'Atri S, Pepponi R, Prete SP, Bonmassar E. In vitro effect of hyperthermia on natural cell-mediated cytotoxicity. Anticancer Res. 2000 May-Jun;20(3A):1667-72. PubMed PMID: 10928089. 56: D'Atri S, Graziani G, Lacal PM, Nisticò V, Gilberti S, Faraoni I, Watson AJ, Bonmassar E, Margison GP. Attenuation of O(6)-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in jurkat cells. J Pharmacol Exp Ther. 2000 Aug;294(2):664-71. PubMed PMID: 10900246. 57: Aquino A, Prete SP, Baier S, Cappelletti D, Greiner JW, De Vecchis L, Graziani G, Bonmassar E. Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line. J Chemother. 2000 Apr;12(2):167-72. PubMed PMID: 10789557. 58: Tricarico M, Rinaldi M, Bonmassar E, Fuggetta MP, Barrera G, Fazio VM. Effect of 4-hydroxynonenal, a product of lipid peroxidation, on natural cell mediated cytotoxicity. Anticancer Res. 1999 Nov-Dec;19(6B):5149-54. PubMed PMID: 10697525. 59: Alvino E, Pepponi R, Pagani E, Lacal PM, Nunziata C, Bonmassar E, D'Atri S. O(6)-benzylguanine enhances the in vitro immunotoxic activity of temozolomide on natural or antigen-dependent immunity. J Pharmacol Exp Ther. 1999 Dec;291(3):1292-300. PubMed PMID: 10565854. 60: Faraoni I, Graziani G, Turriziani M, Masci G, Mezzetti M, Testori A, Veronesi U, Bonmassar E. Suppression of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: in vitro studies with fresh human tumor samples. Lab Invest. 1999 Aug;79(8):993-1005. PubMed PMID: 10462037. 61: Tentori L, Turriziani M, Franco D, Serafino A, Levati L, Roy R, Bonmassar E, Graziani G. Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds. Leukemia. 1999 Jun;13(6):901-9. PubMed PMID: 10360379. 62: Sigala S, Faraoni I, Botticini D, Paez-Pereda M, Missale C, Bonmassar E, Spano P. Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines. Clin Cancer Res. 1999 May;5(5):1211-8. PubMed PMID: 10353759. 63: Tricarico M, Macchi B, D'Atri S, Morrone S, Bonmassar E, Fuggetta MP, Graziani G. In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers. Leukemia. 1999 Feb;13(2):222-9. Erratum in: Leukemia 1999 Jul;13(7):1108. PubMed PMID: 10025896. 64: Alvino E, Fuggetta MP, Tricarico M, Bonmassar E. 2'-2'-difluorodeoxycytidine: in vitro effects on cell-mediated immune response. Anticancer Res. 1998 Sep-Oct;18(5A):3597-602. PubMed PMID: 9858945. 65: Rinaldi M, Tricarico M, Bonmassar E, Parrella P, Barrera G, Fazio VM. Effect of 4-hydroxynonenal, a product of lipid peroxidation, on NK susceptibility of human K562 target cells. Anticancer Res. 1998 Sep-Oct;18(5A):3591-5. PubMed PMID: 9858944. 66: Tonini G, Nunziata C, Prete SP, Pepponi R, Turriziani M, Masci G, Graziani G, Bonmassar E, De Vecchis L. Adjuvant treatment of breast cancer: a pilot immunochemotherapy study with CMF, interleukin-2 and interferon alpha. Cancer Immunol Immunother. 1998 Nov;47(3):157-66. PubMed PMID: 9829841. 67: Aquino A, Prete SP, Greiner JW, Giuliani A, Graziani G, Turriziani M, De Filippi R, Masci G, Bonmassar E, De Vecchis L. Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells. Clin Cancer Res. 1998 Oct;4(10):2473-81. PubMed PMID: 9796980. 68: Lama G, Angelucci C, Bruzzese N, Iacopino F, Nori SL, D'Atri S, Turriziani M, Bonmassar E, Sica G. Sensitivity of human melanoma cells to oestrogens, tamoxifen and quercetin: is there any relationship with type I and II oestrogen binding site expression? Melanoma Res. 1998 Aug;8(4):313-22. Erratum in: Melanoma Res 1999 Oct;9(5):530. PubMed PMID: 9764806. 69: Franzese O, Comandini A, Cannavò E, Pepponi R, Falcinelli S, Graziani G, Bonmassar E. Effect of prostaglandin A1 on proliferation and telomerase activity of human melanoma cells in vitro. Melanoma Res. 1998 Aug;8(4):323-8. 70: Giuliani A, Porcelli SA, Tentori L, Graziani G, Testorelli C, Prete SP, Bussini S, Cappelletti D, Brenner MB, Bonmassar E, Aquino A. Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen. Life Sci. 1998;63(12):985-94. PubMed PMID: 9749821. 71: Levati L, Marra G, Lettieri T, D'Atri S, Vernole P, Tentori L, Lacal PM, Pagani E, Bonmassar E, Jiricny J, Graziani G. Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents. Genes Chromosomes Cancer. 1998 Oct;23(2):159-66. PubMed PMID: 9739019. 72: D'Atri S, Tentori L, Lacal PM, Graziani G, Pagani E, Benincasa E, Zambruno G, Bonmassar E, Jiricny J. Involvement of the mismatch repair system in temozolomide-induced apoptosis. Mol Pharmacol. 1998 Aug;54(2):334-41. PubMed PMID: 9687575. 73: Tentori L, Lacal PM, Benincasa E, Franco D, Faraoni I, Bonmassar E, Graziani G. Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase. J Pharmacol Exp Ther. 1998 May;285(2):884-93. PubMed PMID: 9580640. 74: Fuggetta MP, Tricarico M, Starace G, Pepponi R, Bonmassar E. Interferons antagonize gamma-ray-induced depression of natural immunity. Int J Radiat Oncol Biol Phys. 1998 Mar 1;40(4):953-60. PubMed PMID: 9531381. 75: Tentori L, Graziani G, Porcelli SA, Sugita M, Brenner MB, Madaio R, Bonmassar E, Giuliani A, Aquino A. Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes. Antimicrob Agents Chemother. 1998 Mar;42(3):550-4. PubMed PMID: 9517931; PubMed Central PMCID: PMC105497. 76: Tentori L, Orlando L, Lacal PM, Benincasa E, Faraoni I, Bonmassar E, D'Atri S, Graziani G. Inhibition of O6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Mol Pharmacol. 1997 Aug;52(2):249-58. PubMed PMID: 9271347. 77: Macchi B, Faraoni I, Zhang J, Grelli S, Favalli C, Mastino A, Bonmassar E. AZT inhibits the transmission of human T cell leukaemia/lymphoma virus type I to adult peripheral blood mononuclear cells in vitro. J Gen Virol. 1997 May;78 ( Pt 5):1007-16. PubMed PMID: 9152417. 78: Faraoni I, Turriziani M, Masci G, De Vecchis L, Shay JW, Bonmassar E, Graziani G. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro. Clin Cancer Res. 1997 Apr;3(4):579-85. PubMed PMID: 9815723. 79: Testorelli C, Bussini S, De Filippi R, Marelli O, Orlando L, Greiner JW, Grohmann U, Tentori L, Giuliani A, Bonmassar E, Graziani G. Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene. J Exp Clin Cancer Res. 1997 Mar;16(1):15-22. PubMed PMID: 9148855. 80: Giuliani A, Tentori L, Pepponi R, Porcelli SA, Aquino A, Orlando L, Sugita M, Brenner MB, Bonmassar E, Graziani G. Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3'-azido-3'-deoxythymidine. Pharmacol Res. 1997 Feb;35(2):135-40. PubMed PMID: 9175583. 81: Alvino E, Gilberti S, Cantagallo D, Massoud R, Gatteschi A, Tentori L, Bonmassar E, D'Atri S. In vitro antitumor activity of 3'-desamino-3'(2-methoxy-4-morpholinyl) doxorubicin on human melanoma cells sensitive or resistant to triazene compounds. Cancer Chemother Pharmacol. 1997;40(2):180-4. PubMed PMID: 9182841. 82: Prete SP, Aquino A, Masci G, Orlando L, Giuliani A, De Santis S, De Vecchis L, De Filippi R, Greiner JW, Bonmassar E, Graziani G. Drug-induced changes of carcinoembryonic antigen expression in human cancer cells: effect of 5-fluorouracil. J Pharmacol Exp Ther. 1996 Dec;279(3):1574-81. PubMed PMID: 8968385. 83: Franzese O, Bonmassar E, Marcucci A, D'Onofrio C. Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. Int J Immunopharmacol. 1996 Nov;18(11):609-22. PubMed PMID: 9089005. 84: Lacal PM, D'Atri S, Orlando L, Bonmassar E, Graziani G. In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds. J Pharmacol Exp Ther. 1996 Oct;279(1):416-22. PubMed PMID: 8859021. 85: Pica F, Franzese O, D'Onofrio C, Bonmassar E, Favalli C, Garaci E. Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-Myc-dependent and Bcl-2-independent associated pathway. J Pharmacol Exp Ther. 1996 Jun;277(3):1793-800. PubMed PMID: 8667251. 86: Graziani G, Faraoni I, Grohmann U, Bianchi R, Binaglia L, Margison GP, Watson AJ, Orlando L, Bonmassar E, D'Atri S. O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Cancer Res. 1995 Dec 15;55(24):6231-6. PubMed PMID: 8521419. 87: Tentori L, Leonetti C, Lozupone F, Bonmassar E. Antitumor and antimetastatic effects of dacarbazine combined with cyclophosphamide and interleukin-2 in Lewis lung carcinoma (3LL). Cancer Immunol Immunother. 1995 Dec;41(6):375-83. PubMed 88: Giuliani A, Vernole P, D'Atri S, Del Poeta G, D'Onofrio C, Faraoni I, Greiner JW, Bonmassar E, Graziani G. In vitro infection of leukemic bone marrow with HTLV-I generates immortalized cell lines expressing T or myeloid cell phenotype. Leukemia. 1995 Dec;9(12):2071-81. PubMed PMID: 8609719. 89: Tentori L, Graziani G, Gilberti S, Lacal PM, Bonmassar E, D'Atri S. Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Leukemia. 1995 Nov;9(11):1888-95. PubMed PMID: 7475280. 90: Lu K, Yin MB, McGuire JJ, Bonmassar E, Rustum YM. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. Biochem Pharmacol. 1995 Jul 31;50(3):391-8. PubMed PMID: 7646540. 91: Piccioni D, D'Atri S, Papa G, Caravita T, Franchi A, Bonmassar E, Graziani G. Cisplatin increases sensitivity of human leukemic blasts to triazene compounds. J Chemother. 1995 Jun;7(3):224-9. PubMed PMID: 7562019. 92: D'Onofrio C, Puglianiello A, Amici C, Faraoni I, Lanzilli G, Bonmassar E. HSP70 production and inhibition of cell proliferation in Molt-4 T-cells after cell-to-cell transmission of HTLV-I: effect of PGA1. Leuk Res. 1995 May;19(5):345-56. PubMed PMID: 7769835. 93: D'Onofrio C, Puglianiello A, Lanzilli G, Peci E, Starace G, Bonmassar E. Cell-cycle progression and apoptosis in K562 and Molt-4 cells after cell-to-cell transmission of HTLV-I: modulation by interferons. Cell Death Differ. 1995 Jan;2(1):57-68. PubMed PMID: 17180016. 94: Pica F, Franzese O, D'Onofrio C, Paganini L, Favalli C, Bonmassar E, Garaci E. Effect of PGE2 on c-Myc and Bcl-2 production and programmed cell death in human lymphocytes. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:457-9. PubMed PMID: 7732891. 95: Lacal PM, Amici C, Bonmassar E, D'Onofrio C. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. J Pharmacol Exp Ther. 1994 Nov;271(2):1096-102. PubMed PMID: 7965771. 96: Lacal PM, Puglianiello A, Bonmassar E, D'Onofrio C. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. J Pharmacol Exp Ther. 1994 Nov;271(2):1086-95. PubMed PMID: 7965770. 97: De Filippi R, Prete SP, Giuliani A, Silvi E, Yamaue H, Nieroda CA, Greiner JW, De Vecchis L, Bonmassar E. Differential effects of recombinant interferon-alpha and 5-fluorouracil against colon cancer cells or against peripheral blood mononuclear cells. Anticancer Res. 1994 Sep-Oct;14(5A):1767-73. PubMed PMID: 7847809. 98: D'Atri S, Romani L, Bonmassar E, Grohmann U, Tricarico M, Christmas SE, Moore M. Untreated or drug-treated tumor cells are differentially recognized by allogeneic lymphocytes. Int J Immunopharmacol. 1994 Jul;16(7):569-79. 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PubMed PMID: 8343559. 103: Macchi B, Faraoni I, Mastino A, D'Onofrio C, Romeo G, Bonmassar E. Protective effect of interferon beta on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood. Cancer Immunol Immunother. 1993 Jul;37(2):97-104. PubMed PMID: 8100486. 104: D'Onofrio C, Franzese O, Ricci F, Bonmassar E. Combined treatments with interferon (alpha,beta) plus PGA1 to control early infection with HTLV-I in primary cord blood-derived mononuclear cells. Int J Immunopharmacol. 1993 Feb;15(2):125-36. PubMed PMID: 8468116. 105: Fuggetta MP, Aquino A, Pepponi R, D'Atri S, Lanzilli G, Bonmassar E, Graziani G. In vitro combined effects of human interferons and interleukin-2 on natural cell-mediated cytotoxicity. Int J Immunopharmacol. 1993 Jan;15(1):1-10. PubMed PMID: 7679378. 106: D'Atri S, Papa G, Tuorto V, Piccioni D, Franchi A, Del Poeta G, Bonmassar E. O6-alkylguanine-DNA alkyltransferase activity in blasts obtained from patients with myelogenous or lymphocytic leukemia. Pharmacol Res. 1992 Sep;26 Suppl 2:78-9. PubMed PMID: 1409331. 107: D'Onofrio C, Guerriero M, Bonmassar E. Biological basis for immunopharmacology in the control of early infection with human retroviruses. Pharmacol Res. 1992 Sep;26 Suppl 2:56-7. PubMed PMID: 1329064. 108: D'Onofrio C, Franzese O, Puglianiello A, Peci E, Lanzilli G, Bonmassar E. Antiviral activity of individual versus combined treatments with interferon alpha, beta and gamma on early infection with HTLV-I in vitro. Int J Immunopharmacol. 1992 Aug;14(6):1069-79. PubMed PMID: 1428362. 109: Macchi B, Caronti B, Cocchia D, Gremo F, Torelli S, Sogos V, Bonmassar E, Lauro GM. Correlation between P19 presence and MHC class II expression in human fetal astroglial cells cocultured with HTLV-I donor cells. Int J Dev Neurosci. 1992 Jun;10(3):231-41. 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Ann Oncol. 1991 Nov-Dec;2(10):759-64. PubMed PMID: 1801883. 114: D'Atri S, Marini S, Tentori L, Tricarico M, Fuggetta MP, Bonmassar E. Drug-mediated increase of susceptibility of human lung cancer to NK or LAK effector cells. Immunopharmacology. 1991 May-Jun;21(3):199-210. PubMed PMID: 1917440. 115: Macchi B, Caronti B, Gremo F, Torelli S, Bonmassar E, Lauro GM. HTLV-I neurotropism. In vitro studies. Acta Neurol (Napoli). 1991 Apr;13(2):179-83. Review. PubMed PMID: 1891983. 116: D'Onofrio C, Alvino E, Peci E, Caliò R, Bonmassar E. Differential interference of alpha, beta or gamma interferons with HTLV-I integration and expression in vitro. Ann Ist Super Sanita. 1991;27(1):127-32. PubMed PMID: 1958020. 117: Macchi B, Caronti B, Pezzella M, Bonmassar E, Lauro G. Effect of human T lymphotropic retrovirus-I exposure on cultured human glioma cell lines. Acta Neuropathol. 1991;81(6):670-4. PubMed PMID: 1882642. 118: Giuliani A, D'Atri S, Franchi A, Tricarico M, Tentori L, Bonmassar E. Chemical xenogenization: antigenic changes of cancer cells induced by triazene compounds. Contrib Gynecol Obstet. 1991;18:79-92. Review. PubMed PMID: 1718661. 119: D'Onofrio C, Bonmassar E. An immunopharmacological approach for prevention of retrovirus-associated disease in human pathology. Pharmacol Res. 1990 Nov-Dec;22(6):645-59. Review. PubMed PMID: 1963684. 120: D'Onofrio C, Amici C, Bonmassar E, Santoro MG. The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. Pharmacol Res. 1990 Sep-Oct;22 Suppl 1:41-2. PubMed PMID: 2284244. 121: Macchi B, D'Onofrio C, Labianca RA, Bonmassar E. Mononuclear cells from peripheral blood of adult donors and from cord blood are equally protected by alpha- and beta-interferons against infection with HTLV-I. Pharmacol Res. 1990 Jul-Aug;22(4):503-14. PubMed PMID: 2205849. 122: Neri M, Zei T, Rossi GB, Coccia EM, Bonmassar E, Iorio AM. Effect of in vitro interferon treatment on the rapid clearance of murine leukemia cells in vivo. J Biol Regul Homeost Agents. 1990 Apr-Jun;4(2):60-6. PubMed PMID: 1701956. 123: Greco C, Del Bufalo D, Giannarelli D, Marangolo M, Fuggetta MP, Bonmassar E, Zupi G. N-methylformamide affects spontaneous metastases of 3LL lines and increases natural killer activity of tumor-bearing mice. Clin Exp Metastasis. 1990 Mar-Apr;8(2):153-63. PubMed PMID: 2317955. 124: D'Onofrio C, Alvino E, Garaci E, Bonmassar E, Santoro MG. Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. Br J Cancer. 1990 Feb;61(2):207-14. PubMed PMID: 2310673; PubMed Central PMCID: PMC1971418. 125: Tentori L, Leonetti C, Lanzilli G, Bonmassar E. IL-2 reverses the inhibition of cytotoxic T-cell responses induced by 5-(3,3' dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in vitro. Int J Immunopharmacol. 1990;12(8):831-40. PubMed PMID: 2292462. 126: D'Onofrio C, Pesce CD, Fontana T, Ciprani F, Bonmassar E, Caliŏ R. Modulation of the cell-mediated immune function by interferon alpha, beta or gamma can partially reverse the immunosuppression induced by human T-cell leukemia virus I in human cord blood cultures. Cancer Immunol Immunother. 1990;31(4):213-20. PubMed PMID: 2116232. 127: Fuggetta MP, D'Onofrio C, Bonmassar E. Role of biological response modifiers in immunochemotherapy of solid tumors and retroviral-induced leukemia. Ann Ist Super Sanita. 1990;26(3-4):385-95. Review. PubMed PMID: 1708953. 128: Mastino A, Favalli C, Moras ML, Grelli S, Bonmassar E. Flow cytometric method for the evaluation of the biological activity of thymic hormones. J Chemother. 1989 Jul;1(4 Suppl):459-60. PubMed PMID: 16312484. 129: Neri M, Zei T, Bonmassar E, Rossi GB, Fiorucci G, Iorio AN. Natural resistance in mice against Friend cells injected intravenously. III. Comparison between in vivo and in vitro passaged interferon-sensitive (745) and interferon-resistant (3Cl8) cell clones. Br J Cancer. 1989 Jun;59(6):848-53. PubMed PMID: 2736222; PubMed Central PMCID: PMC2246741. 130: De Vecchis L, Nunziata C, Ricci F, Cucchiara G, Picconi A, Bonmassar G, Lagomarsino Caprino M, Bonmassar E. Immunochemotherapy of advanced colorectal cancer with alpha-interferon and 5-fluorouracil. 1. Toxicological studies. J Chemother. 1989 Apr;1(2):128-35. PubMed PMID: 2732781. 131: Iorio AM, Neri M, Zei T, Romeo G, Rossi GB, Bonmassar E. Natural resistance in mice against Friend leukemia cells. II. Studies with in vivo passaged interferon-sensitive and interferon-resistant cell clones. Cell Immunol. 1989 Feb;118(2):425-34. PubMed PMID: 2463101. 132: Ballerini P, Franchi A, Fuschiotti P, Piccioni D, Bonmassar E. Two antiemetic regimens do not impair chemical xenogenization induced in vivo by 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide. Cancer Chemother Pharmacol. 1989;24(6):359-62. PubMed PMID: 2791188. 133: Vernole P, Caporossi D, Tedeschi B, Melino G, Porfirio B, Bonmassar E, Nicoletti B. Sister-chromatid exchanges in human lymphocytes exposed to 1-p-(3-methyltriazeno)benzoic acid potassium salt. Mutat Res. 1988 Jul;208(3-4):233-6. PubMed PMID: 3398873. 134: D'Onofrio C, Perno CF, Mazzetti P, Graziani G, Calio' R, Bonmassar E. Depression of early phase of HTLV-I infection in vitro mediated by human beta-interferon. Br J Cancer. 1988 May;57(5):481-8. PubMed PMID: 2899440; PubMed Central PMCID: PMC2246394. 135: D'Atri S, Fuggetta MP, Giganti G, Tentori L, Roselli M, Nunziata C, Pastore S, Bonmassar E, De Vecchis L. Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy. Cancer Immunol Immunother. 1988;27(2):163-70. PubMed PMID: 3416325. 136: Fuggetta MP, Graziani G, Aquino A, D'Atri S, Bonmassar E. Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon. Int J Immunopharmacol. 1988;10(6):687-94. PubMed PMID: 3198305. 137: Pesce CD, Ciprani F, D'Onofrio C, Alvino E, Perno CF, Bonmassar E, Caliò R. Low concentrations of suramin can reduce in vitro infection of human cord blood lymphocytes with HTLV-I during long-term culture. Antiviral Res. 1987 Dec;8(5-6):247-60. PubMed PMID: 2897831. 138: Martelletti P, Stirparo G, De Stefano L, Bonmassar E, Giacovazzo M, Rinaldi-Garaci C. Reduced activity of the NK cells from patients with cluster headache and the "in vitro" response to beta-interferon. Headache. 1987 Nov;27(10):548-51. PubMed PMID: 3692817. 139: Vernole P, Caporossi D, Tedeschi B, Porfirio B, Melino G, Bonmassar E, Nicoletti B. Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on human lymphocytes in vitro. Mutat Res. 1987 Nov;189(3):349-56. PubMed PMID: 3670338. 140: Iorio AM, Neri M, Bonmassar E, Titti F, Rossi GB. In vivo natural antitumor resistance against murine EL-4 lymphoma cells in lethally irradiated syngeneic C57Bl/6 mice. Cell Immunol. 1987 Aug;108(1):85-96. PubMed PMID: 3607887. 141: Macchi B, Popovic M, Allavena P, Ortaldo J, Rossi P, Gallo RC, Bonmassar E. In vitro susceptibility of different human T-cell subpopulations and resistance of large granular lymphocytes to HTLV-I infection. Int J Cancer. 1987 Jul 15;40(1):1-6. PubMed PMID: 2885278. 142: Graziani G, Pasqualetti D, Lopez M, D'Onofrio C, Testi AM, Mandelli F, Gallo RC, Bonmassar E. Increased susceptibility of peripheral mononuclear cells of leukemic patients to HTLV-I infection in vitro. Blood. 1987 Apr;69(4):1175-81. PubMed PMID: 2881587. 143: Tentori L, Fuggetta MP, D'Atri S, Aquino A, Nunziata C, Roselli M, Ballatore P, Bonmassar E, De Vecchis L. Influence of low-dose beta-interferon on natural killer cell activity in breast cancer patients subjected to chemotherapy. Cancer Immunol Immunother. 1987;24(1):86-91. PubMed PMID: 3815421. 144: Macchi B, Popovic M, Allavena P, Rossi P, Gallo RC, Bonmassar E. Differential susceptibility of human mononuclear cells to infection with HTLV-I. Int J Tissue React. 1987;9(3):195-8. PubMed PMID: 3036735. 145: Giacovazzo M, Stirparo G, De Stefano L, Rinaldi-Garaci C, Bonmassar E, Martelletti P. Connection between lower natural killer function and susceptibility to viral infection in cluster headache. Cephalalgia. 1987;7 Suppl 6:84-6. PubMed PMID: 2832062. 146: Marini S, Guadagni F, Bonmassar E, Potenza P, Giuliani A. Influence of interferon on the functional expression of natural killer target structures of murine lymphoma cells. Cell Immunol. 1986 Oct 1;102(1):113-25. PubMed PMID: 3802199. 147: Iorio A, Neri M, Federico M, Rossi GB, Bonmassar E. Natural resistance in mice against Friend leukemia cells. I. Studies with in vitro passaged interferon-sensitive and interferon-resistant cell clones. Cell Immunol. 1986 Mar;98(1):230-7. PubMed PMID: 2427224. 148: Menconi E, Lepri E, Bonmassar E, Frati L, Barzi A. An in vitro assay for evaluating chemosensitivity of leukaemia cells: preclinical studies. Int J Tissue React. 1986;8(6):485-92. PubMed PMID: 3793386. 149: D'Atri S, Tentori L, Fuggetta MP, Marini S, Bonmassar E. A miniaturized cell-mediated cytotoxicity assay with human effector mononuclear cells. Int J Tissue React. 1986;8(5):383-90. PubMed PMID: 3536780. 150: Tentori L, Alvino E, Fuggetta MP, D'Atri S, Giganti MG, Caliendo R, Bonmassar E. Natural cell-mediated cytotoxicity: a micro assay suitable for clinical tests. Chemioterapia. 1985 Dec;4(6):471-4. PubMed PMID: 3868428. 151: Marconi P, Scaringi L, Tissi L, Boccanera M, Bistoni F, Bonmassar E, Cassone A. Induction of natural killer cell activity by inactivated Candida albicans in mice. Infect Immun. 1985 Oct;50(1):297-303. PubMed PMID: 3899934; PubMed Central PMCID: PMC262171. 152: Campanile F, Fioretti MC, Bonmassar E, Puccetti P. Evaluation of antibacterial activity in experimental meningo-encephalitis in mice. J Antibiot (Tokyo). 1985 Aug;38(8):1083-7. PubMed PMID: 3930455. 153: Campanile F, Fioretti MC, Bonmassar E, Puccetti P. [Antibacterial activity of antibiotics in experimental encephalitis. An indirect approach to the evaluation of the pharmacokinetic pattern]. G Ital Chemioter. 1985 Jan-Apr;32(1):225-8. Italian. PubMed PMID: 3830783. 154: De Vecchis L, Graziani G, Macchi B, Grandori C, Pastore S, Popovic M, Gallo RC, Bonmassar E. Decline of natural cytotoxicity of human lymphocytes following infection with human T-cell leukemia/lymphoma virus (HTLV). Leuk Res. 1985;9(3):349-55. PubMed PMID: 2987620. 155: Giuliani-Bonmassar A, Graziani G, Frati L, Bonmassar E. Interferon-induced changes in the susceptibility of murine and human lymphoma cells to natural cytotoxic lymphocytes. Int J Tissue React. 1984;6(1):35-41. PubMed PMID: 6585352. 156: Nardelli B, Puccetti P, Romani L, Sava G, Bonmassar E, Fioretti MC. Chemical xenogenization of murine lymphoma cells with triazene derivatives: immunotoxicological studies. Cancer Immunol Immunother. 1984;17(3):213-7. PubMed PMID: 6566603. 157: Campanile F, Puccetti P, Angeli G, Fioretti MC, Bonmassar E. Experimental studies on mice challenged intracerebrally with Pseudomonas aeruginosa. Int J Tissue React. 1984;6(5):421-6. PubMed PMID: 6519921. 158: Migliorati G, Frati L, Pastore S, Bonmassar E, Riccardi C. Increase of natural killer (NK) activity of mouse lymphocytes following in vitro treatment with cytosine-arabinoside. Int J Immunopharmacol. 1984;6(5):433-43. PubMed PMID: 6500781. 159: Campanile F, Iorio AM, Bonmassar E. Natural resistance of mice pretreated with 5-(3,3'-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) + cyclophosphamide (Cy) against virus-induced lymphoma cells. Int J Immunopharmacol. 1984;6(4):251-8. PubMed PMID: 6480192. 160: Iorio AM, Neri M, Enrico P, Titti F, Rossi GB, Bonmassar E. Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus. Cancer Immunol Immunother. 1984;18(1):35-40. PubMed PMID: 6149016. 161: Fioretti MC, Bianchi R, Romani L, Bonmassar E. Drug-induced immunogenic changes of murine leukemia cells: dissociation of onset of resistance and emergence of novel immunogenicity. J Natl Cancer Inst. 1983 Dec;71(6):1247-51. PubMed PMID: 6581361. 162: Marconi P, Cassone A, Baccarini M, Tissi L, Garaci E, Bonmassar E, Frati L, Bistoni F. Relationships among tumor load, route of tumor inoculation, and response to immunochemotherapy in a murine lymphoma model. J Natl Cancer Inst. 1983 Aug;71(2):299-307. PubMed PMID: 6348362. 163: Migliorati G, Jezzi T, Frati L, Bonmassar E, Rossi GB, Garaci E, Riccardi C. Modulation of natural killer (nk) cell activity during FLV-P virus infection of mice. Int J Cancer. 1983 Jan 15;31(1):81-90. PubMed PMID: 6219962. 164: Rivosecchi Merletti P, Bianchi R, Nardelli B, Iorio AM, Campanile F, Migliorati G, Bonmassar E. Immunobiological aspects of the nude mouse model relative to human cancer chemosensitivity tests. Int J Tissue React. 1983;5(1):19-27. PubMed PMID: 6862787. 165: Fioretti MC, Romani L, Bonmassar E. Antigenic changes related to drug action. Prog Clin Biol Res. 1983;132B:435-45. PubMed PMID: 6634765. 166: Romani L, Migliorati G, Bonmassar E, Fioretti MC. Susceptibility of murine lymphoma cells treated with 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide to NK-mediated cytotoxicity in vitro. Int J Immunopharmacol. 1983;5(4):299-306. PubMed PMID: 6629590. 167: Bistoni F, Marconi P, Frati L, Bonmassar E, Garaci E. Increase of mouse resistance to Candida albicans infection by thymosin alpha 1. Infect Immun. 1982 May;36(2):609-14. PubMed PMID: 7085074; PubMed Central PMCID: PMC351272. 168: Romani L, Fioretti MC, Bianchi R, Nardelli B, Bonmassar E. Intracerebral adoptive immunotherapy of a murine lymphoma antigenically altered by drug treatment in vivo. J Natl Cancer Inst. 1982 May;68(5):817-22. PubMed PMID: 7040772. 169: Marconi P, Cassone A, Tissi L, Baccarini M, Puccetti P, Garaci E, Bonmassar E, Bistoni F. Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model. Int J Cancer. 1982 Apr 15;29(4):483-8. PubMed PMID: 7044994. 170: Circolo A, Bianchi R, Nardelli B, Rivosecchi-Merletti P, Bonmassar E. Mouse brain: an immunologically privileged site for natural resistance against lymphoma cells. J Immunol. 1982 Feb;128(2):556-62. PubMed PMID: 7054288. 171: Marconi P, Bistoni F, Cassone A, Frati L, Baccarini M, Garaci E, Bonmassar E. The role of the peritoneal cavity in successful treatment of a murine lymphoma with chemotherapy and non-specific immunostimulation. Cancer Immunol Immunother. 1982;13(2):128-33. PubMed PMID: 6760959. 172: Puccetti P, Romani L, Taramelli D, Bonmassar E, Fioretti MC. Drug-mediated changes of tumour cell immunogenicity and antigenicity. Int J Tissue React. 1982;4(3):189-99. PubMed PMID: 6183194. 173: Iorio AM, Neri M, Enrico P, Bonmassar E. Inhibition of hybrid resistance to lymphomas by inactivated tumor cells in lethally irradiated mice. Transplantation. 1981 Nov;32(5):355-62. PubMed PMID: 6173939. 174: Iorio AM, Neri M, Enrico P, Goldin A, Bonmassar E. Combined effects of natural resistance and chemotherapy against a murine lymphoma in lethally-irradiated mice. Int J Cancer. 1981 Oct 15;28(4):497-502. PubMed PMID: 7030970. 175: Garaci E, Migliorati G, Jezzi T, Bartocci A, Gioia L, Rinaldi C, Bonmassar E. Impairment of in vitro generation of cytotoxic or T suppressor lymphocytes by Friend leukemia virus infection in mice. Int J Cancer. 1981 Sep 15;28(3):367-73. PubMed PMID: 6459295. 176: Giampietri A, Bonmassar A, Puccetti P, Circolo A, Goldin A, Bonmassar E. Drug-mediated increase of tumor immunogenicity in vivo for a new approach to experimental cancer immunotherapy. Cancer Res. 1981 Feb;41(2):681-7. PubMed PMID: 7448813. 177: Bonmassar A, Rivosecchi-Merletti P, Barzi A, Goldin A, Bonmassar E. Transplantation resistance of drug-treated allogeneic mice against murine lymphomas--II. Studies with various tumor-host combinations. Int J Immunopharmacol. 1981;3(4):391-9. PubMed PMID: 7333720. 178: Migliorati G, Frati L, Barzi A, Bonmassar E. Influence of Ara-C on effector activity of cytotoxic T-lymphocytes in vitro. J Immunopharmacol. 1981;3(1):17-27. PubMed PMID: 6972977. 179: Bonmassar A, Riccardi C, Rivosecchi-Merletti P, Goldin A, Bonmassar E. Transplantation resistance of drug-treated hybrid or allogeneic mice against murine lymphomas. I. Immunopharmacology studies. Int J Cancer. 1980 Dec 15;26(6):819-29. PubMed PMID: 6971268. 180: Giampietri A, Fioretti MC, Goldin A, Bonmassar E. Drug-mediated antigenic changes in murine leukemia cells: antagonistic effects of quinacrine, an antimutagenic compound. J Natl Cancer Inst. 1980 Feb;64(2):297-301. PubMed PMID: 6928222. 181: Bartocci A, Riccardi C, Bonmassar E. In vivo or in vitro modulating effects of vincristine on the generation of allogeneic cytotoxic lymphocytes in vitro. J Immunopharmacol. 1980;2(1):61-72. PubMed PMID: 7452004. 182: Riccardi C, Bartocci A, Puccetti P, Spreafico F, Bonmassar E, Goldin A. Combined effects of antineoplastic agents and anti-lymphoma allograft reactions. Eur J Cancer. 1980 Jan;16(1):23-33. PubMed PMID: 7358077. 183: Goldin A, Nicolin A, Bonmassar E. Chemotherapy immunogenicity. Recent Results Cancer Res. 1980;75:185-94. PubMed PMID: 7232831. 184: Campanile F, Bonmassar E. Differential graft resistance of C3H mice pretreated with antitumor drugs against BALB/c bone marrow or lymphoma cells. J Immunopharmacol. 1980;2(4):527-42. PubMed PMID: 7009759. 185: Santoni A, Puccetti P, Riccardi C, Herberman RB, Bonmassar E. Augmentation of natural killer activity by pyran copolymer in mice. Int J Cancer. 1979 Nov 15;24(5):656-61. PubMed PMID: 528080. 186: Bistoni F, Marconi P, Pitzurra M, Frati L, Spreafico F, Goldin A, Bonmassar E. Combined effects of BCG or Candida albicans (CA) with antitumor agents against a virus-induced lymphoma in mice. Eur J Cancer. 1979 Nov;15(11):1305-14. PubMed PMID: 393515. 187: Romani L, Fioretti MC, Bonmassar E. In vitro generation of primary cytotoxic lymphocytes against L5178Y leukemia antigenically altered by 5-(3,3'-dimethyl-1-triazeno)-imidazole-4-carboxamide in vivo. Transplantation. 1979 Sep;28(3):218-22. PubMed PMID: 494379. 188: Riccardi C, Puccetti P, Santoni A, Herberman RB, Bonmassar E. Adriamycin-induced antitumor response in lethally irradiated mice. Immunopharmacology. 1979 Jun;1(3):211-20. PubMed PMID: 233585. 189: Fioretti MC, Bonmassar E. [Experimental model for the study of antitumor immunity combined action drugs]. G Ital Chemioter. 1979 Jan-Dec;26(1-2):357-62. Italian. PubMed PMID: 554824. 190: Merletti PR, Giovanella B, Bonmassar E, Goldin A. Growth and inhibition of mouse or human tumors in "nude" (athymic) mice monitored by the extent of 125 I-5-Iodo-2'-deoxyuridine(125-IUdR) uptake. Eur J Cancer. 1978 Oct;14(10):1057-64. PubMed PMID: 710476. 191: Iorio A, Campanile F, Neri M, Spreafico F, Goldin A, Bonmassar E. Inhibition of lymphoma growth in the spleen and liver of lethally irradiated mice. J Immunol. 1978 May;120(5):1679-85. PubMed PMID: 659871. 192: Riccardi C, Fioretti MC, Giampietri A, Puccetti P, Goldin A, Bonmassar E. Growth inhibition of normal or drug-treated lymphoma cells in lethally irradiated mice. J Natl Cancer Inst. 1978 May;60(5):1083-90. PubMed PMID: 642028. 193: Goldin A, Nicolin A, Bonmassar E. Interrelationship between chemotherapy and immunotherapy in the treatment of disseminated disease. Recent Results Cancer Res. 1978;68:458-64. PubMed PMID: 752882. 194: Frati L, Riccardi C, Bartocci A, Bonmassar E. New preclinical models for testing antitumor drugs. The immuno-chemotherapy index. Arch Geschwulstforsch. 1978;48(7):660-4. PubMed PMID: 736747. 195: Giampietri A, Bonmassar E, Goldin A. Drug induced modulation of immune responses in mice: effects of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) and cyclophosphamide (Cy). J Immunopharmacol. 1978-1979;1(1):61-86. PubMed PMID: 401314. 196: Frati L, Barzi A, Caprino MC, Menconi E, Bonmassar E. Immunostimulation before chemotherapy in cancer treatment. Pharmacol Res Commun. 1977 Sep;9(8):689-99. PubMed PMID: 563086. 197: Campanile F, Crino L, Bonmassar E, Houchens D, Goldin A. Radioresistant inhibition of lymphoma growth in congenitally athymic (nude) mice. Cancer Res. 1977 Feb;37(2):394-8. PubMed PMID: 832264. 198: Iorio AM, Barzi A, Merletti PR, Goldin A, Bonmassar E. A viral immunodepressive factor associated with experimental mouse tumors. Cancer Res. 1976 Oct;36(10):3851-3. PubMed PMID: 954006. 199: Bonmassar E, Cudkowicz G. Suppression of allogeneic lymphomas in spleens of irradiated mice: importance of the D end of the H-2 complex. J Immunol. 1976 Aug;117(2):697-700. PubMed PMID: 781136. 200: Houchens DP, Bonmassar E, Gaston MR, Kende M, Goldin A. Drug-mediated immunogenic changes of virus-induced leukemia in vivo. Cancer Res. 1976 Apr;36(4):1347-52. PubMed PMID: 1260759. 201: Nicolin A, Spreafico F, Bonmassar E, Goldin A. Antigenic changes of L5178Y lymphoma after treatment with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide in vivo. J Natl Cancer Inst. 1976 Jan;56(1):89-93. PubMed PMID: 1255754. 202: Bonmassar E, Campanile F, Houchens D, Crino L, Goldin A. Impaired growth of a radiation-induced lymphoma in intact or lethally irradiated allogeneic athymic (nude) mice. Transplantation. 1975 Oct;20(4):343-6. PubMed PMID: 1162722. 203: Houchens DP, Iorio A, Barzi A, Goldin A, Bonmassar E. Inhibition of antilymphoma allograft response in normal and lethally irradiated mice by cyclophosphamide (NSC-26271) and isophosphamide (NSC-109724). Cancer Chemother Rep. 1975 Sep-Oct;59(5):967-73. PubMed PMID: 1203899. 204: Bonmassar E, Testorelli C, Franco P, Goldin A, Cudkowicz G. Changes of the immunogenic properties of a radiation-induced mouse lymphoma following treatment with antitumor drugs. Cancer Res. 1975 Aug;35(8):1957-62. PubMed PMID: 1149019. 205: Campanile F, Houchens DP, Gaston M, Goldin A, Bonmassar E. Increased immunogenicity of two lymphoma lines after drug treatment of athymic (nude) mice. J Natl Cancer Inst. 1975 Jul;55(1):207-9. PubMed PMID: 1159815. 206: Bonmassar A, Fioretti MC, Bonmassar E, Goldin A. Allograft reactivity of mice against a radiation-induced lymphoma incompatibile for the H-2K-Ir regions of H-2. Eur J Cancer. 1975 Feb;11(2):71-8. PubMed PMID: 1093850. 207: Bonmassar E, Houchens DP, Fioretti MC, Goldin A. Uptake of 5-iododeoxyuridine as a measure of tumor growth and tumor inhibition. Chemotherapy. 1975;21(6):321-9. PubMed PMID: 1183242. 208: Fioretti MC, Libarati M, Bonmassar E, Cudkowicz G. Immune inhibition of allogeneic lymphoma cells in the peritoneal cavity of mice. Cancer Res. 1975 Jan;35(1):30-6. PubMed PMID: 1089042. 209: Bonmassar E, Menconi E, Goldin A, Cudkowicz G. Escape of small numbers of allogeneic lymphoma cells from immune surveillance. J Natl Cancer Inst. 1974 Aug;53(2):475-9. PubMed PMID: 4843273. 210: Bonmassar E, Bonmassar A, Goldin A, Cudkowicz G. Depression of antilymphoma allograft reactivity by tumor-associated factors. Cancer Res. 1973 May;33(5):1054-61. PubMed PMID: 4703118. 211: Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A. Antigenic changes of L1210 leukemia in mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide. Cancer Res. 1972 Jul;32(7):1446-50. PubMed PMID: 4402275. 212: Bonmassar E, Goldin A, Cudkowicz G. Differential reactivity of mice to alloantigens associated with the D and K end of H-2: preliminary studies with bone marrow and lymphoma grafts. Transplantation. 1971 Oct;12(4):314-8. PubMed PMID: 4107113. 213: Bonmassar E, Goldin A, Cudkowicz G. Differential immunogenicity of H-2 alloantigens: a sensitive immuno-pharmacologic test. Proc Soc Exp Biol Med. 1971 Sep;137(4):1486-9. PubMed PMID: 5138477. 214: Vadlamudi S, Padarathsingh M, Bonmassar E, Waravdekar V, Goldin A. Studies on neutralization of L-asparaginase activity in vitro and in vivo. Cancer. 1971 Jun;27(6):1321-7. PubMed PMID: 4996690. 215: Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A. Immunologic response of mice bearing leukemia L1210. Cancer. 1971 Jun;27(6):1356-62. PubMed PMID: 4932473. 216: Vadlamudi S, Padarathsingh M, Bonmassar E, Goldin A. Effect of combination treatment with cyclophosphamide and isogeneic or allogeneic spleen and bone marrow cells in leukemic (L1210) mice. Int J Cancer. 1971 Jan 15;7(1):160-6. PubMed PMID: 4925903. 217: Bonmassar E, Cudkowicz G, Vadlamudi S, Goldin A. Influence of tumor-host differences at a single histocompatibility locus (H-1) on the antileukemic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962). Cancer Res. 1970 Oct;30(10):2538-42. PubMed PMID: 5474176. 218: Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A. Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug. Proc Natl Acad Sci U S A. 1970 Aug;66(4):1089-95. PubMed PMID: 5273445; PubMed Central PMCID: PMC335790. 219: Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A. Primary antibody response in mice bearing leukemia L1210. Experientia. 1970 May 15;26(5):529-31. PubMed PMID: 5462857. 220: Vadlamudi S, Padarathsingh M, Bonmassar E, Goldin A. Reduction of antileukemic and immunosuppressive activities of 5-azacytidine in mice by concurrent treatment with uridine. Proc Soc Exp Biol Med. 1970 Apr;133(4):1232-8. PubMed PMID: 4909392. 221: Bonmassar E. [Use of the scanning electron microscope in pharmacognosic research. Studies of the bark of some species of Rhamnus]. Atti Accad Med Lomb. 1970;25(2-3):175-82. Italian. PubMed PMID: 5538482. 222: Bonmassar E, Dalla Valle R, Scaglione V. [Effects of estrone pretreatment on the growth and response of Ehrlich's ascites tumor to 5-fluorouracil]. Arch Ital Patol Clin Tumori. 1968 Jul-Dec;11(3):263-9. Italian. PubMed PMID: 5737807. 223: Bonmassar E, Celi ML, Melan F, Testorelli C. [Influence of epsilon-aminocaproic acid on the growth of tumor cells in immunized mice]. Arch Ital Patol Clin Tumori. 1968 Jan-Jun;11(1):187-94. Italian. PubMed PMID: 5745501. 224: Bonmassar E, Dallavalle R, Giuliani G. [Influence of vitamin E and propylgallate on cancerogenesis with benzopyrene in mice]. Arch Ital Patol Clin Tumori. 1968 Jan-Jun;11(1):245-50. Italian. PubMed PMID: 5745132. 225: Bonmassar E, Melan F, Testorelli C. [On sensitivity to sarcolysine of Ehrlich's ascites tumors in mice "vaccinated" with treated tumor cells from animals previously treated with sarcolysine alone or with other antineoplastic drugs (thioguanine, actinomycin D)]. Arch Ital Patol Clin Tumori. 1968 Jan-Jun;11(1):229-44. Italian. PubMed PMID: 5745130. 226: Bonmassar E, Castagnone D, Celi ML, Melan F. [Interference of immunological factors in the antitumoral activity of sarcolysine]. Arch Ital Patol Clin Tumori. 1968 Jan-Jun;11(1):215-28. Italian. PubMed PMID: 5745129. 227: Bonmassar E, Melan F, Montagnani-Marelli A. [The influence of an anabolic hormone (dimethazine) on the immunological state of the mouse toward Ehrlich's ascitic carcinoma]. Arch Ital Patol Clin Tumori. 1967 Jan-Jun;10(1):37-40. Italian. PubMed PMID: 5600140. 228: Bertelli A, Bonmassar E, Montagnani-Marelli A, Zannini E. [On a new antibiotic of streptomycetic origin active against Ehrlich's ascitic carcinoma]. Arch Ital Patol Clin Tumori. 1967 Jan-