Prof. Flavia Franconi

Prof. Flavia Franconi

Specialista in Farmacologia medica

Medico Ospedaliero
Prov. di Sassari
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Medico Chirurgo Specialista in Farmacologia medica
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Farmacologia medica
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[b]Istruzione: [/b] Maturità Scientifica e Linguistca Laurea in Medicina e Chirurgia presso l'Università di Firenzecon 110/110 e lode Specializzazione in Psichiatria presso l'Università di Firenze. Inviting Professor presso la Johnson Foundation, University of Pennsylvania. [b]Posizioni accademiche: [/b] Professore ordinario Di Farmacologica Cellulare e Molecolare della Facoltà di Farmacia dell'Università di Sassari dal 1986. [b]Comitati Scientifici:[/b] International Symposium on sulfur amino acid, peptides and related compounds: Firenze- San Miniato, 6-9 Ottobre 1986. Functional neurochemistry of taurine, Huelva (Spagna) 12-19 aprile 1988. International Taurine Symposium: New dimension on its mechanism, Mobile (Alabama) 8-10 ottobre 1991. Role of G proteins in Signal Transduction in Health and disease. Sassari, June 1, 1993. Il Concetto di vulnerabilità biologica nelle Tossico-dipendenze Firenze, 27 febbraio, 1996. 1 seminario Farmaci e Donne Sassari 2004 2 seminario Farmaci e Donne, Roma 13-14 ottobre 2006 3 seminario Salute della Donna, Roma 9-10 Dicembre 2008 Genes, Drugs and Gender Sassari 1-2 ottobre 2009 [b]Iscrizioni a società scientifiche: [/b] Società Italiana di Farmacologia European Heart Society International Society of Miochemistry. New York Accademy of Science. [b]Attività pubblicistica: [/b] The Biology of Taurine: Methods and Mechanisms; Eds. Huxtable R.J., F. Franconi, A. Giotti, Plenum P.Co.New York, 1987. Farmacologia e Tossicologia Sperimentale Eds P.Dolara, F. Franconi, A. Mugelli, Pitagora, Bologna, 1989. Direttore: Quaderni della SIF [b] Commissioni nazionali:[/b] Ex Membro della Commissione Consultiva Tossicologica Nazionale. Ex Membro del Comitato Tecnico della consulta nazionale per l'alimentazione e la sicurezza degli alimenti. Ex Esperto sottogruppo sanitario commissione consultiva presidi sanitari. Membro della Commissione del Ministero della Salute Menopausa 2002-2004 Membro della Commissione del Ministero della Salute: Sperimentazione Farmacologica in ambito femminile ed utilizzo dei farmaci gender-oriented” Membro della Commissione della Salute della Donna del Ministro della Salute e responsabile del vi sottogruppo Membro Commissione AIFA “Valutazione Piani di Settore” [b]Commisione Regionali:[/b] Commissione del Prontuario Regione Sardegna Commissione Terapeutica Regionale della Sardegna [b]Expert: [/b] Gender Basic project of UE www.Vitasearch.com in the Experts Speak Archives [b]Referee: [/b] Alcohol and Alcoholism American Journal of Clinical Nutrition Archives of Medical Research British Journal Clinical Nutrition Diabetologia European Journal Nutrition Food and Chemical Toxicology IUBMB Life Life Science Molecular Nutrition & Food Research Pharmacological Research [b]Altre attività:[/b] Coordinatore del gruppo di Studio della Farmacologia gender-oriented della Società Italiana di Farmacologia Coordinatore del dottorato di Ricerca “Farmacologia di Genere” nell’ambito della Scuola di dottorato “Scienze Biomediche” dell’Università di Sassari Referees del MIUR, del CIVR e della UE Membro del Comitato etico dell’ Istituto Nazionale Malattie Infettive L. Spallanzani Membro della Giunta Centro di Eccellenza per lo Sviluppo della Ricerca Biotecnologia e della Biodiversità, Università di Sassari Membro Commissione Pari Opportunità di Sassari Membro del consiglio direttivo del consorzio Interuniversitario Biostrutture e Biosistemi (INBB) Membro Giunta del consorzio Interuniversitario Biostrutture e Biosistemi (INBB) Vicepresidente Società Italiana per La Salute e la Medicina di Genere [b]Elenco delle pubblicazioni su riviste e libri: [/b] 1. Fantozzi R, Franconi F, Mannaioni PF, Masini E, Moroni F. Interaction of histamine H1 and H2-receptor antagonist with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells "in vitro". Brit J Pharmacol 53, 569, 1975. 2. Giotti A, Zilletti L, Franconi F. Inibitori della prosta-glandino-sintetasi e fenomeni anafilattici. Folia Allerg Immunol Clin 22, 293, 1975. 3. Dolara P, Franconi F. Hypertonic sodium chloride and lidocaine in a case of impramine intoxication. Clin Toxicol 10, 395, 1977. 4. Dolara P, Franconi F, Manghi N. The effect of phalloidin on natural and U.V. denaturated bovine serum albumin. Pharmacol Res Comm 9, 339, 1977. 5. Dolara P, Franconi F, Basosi D. Urinary excretion of some n-hexane metabolites. Pharmacol Res Comm 10, 503, 1978. 6. Dolara P, Ledda F, Mugelli A, Mantelli L, Zilletti L, Franconi F, Giotti A. Effect of taurine on calcium inotropism and electrical activity of the heart. In: Taurine and neurological disorders, Eds A. Barbeau, R.J. Huxtable, Raven Press.,N.Y., 151, 1978. 7. Dolara P, Franconi F, Giotti A, Basosi R, Valensin G. Taurine calcium interaction measured by means of 13C nuclear magnetic resonance. Biochem. Pharmacol. 27, 803, 1978. 8. Franconi F, Manghi N, Giotti A, Martini F, Dini G. Effect of selenium on the contractile force of isolated and perfused guinea-pig heart. Acta Pharmacol. Toxicol. 46, 98, 1980. 9. Blandina P, Fantozzi R, Franconi F, Giotti A, Mannaioni PF, Masini E, Zilletti L. Modulazione adrenergica della broncoreattività, correlazioni farmacologiche cliniche. Folia Allerg Immunol. Clin 27, 1, 1980. 10. Zilletti L, Giotti A, Mannaioni PF, Masini E Franconi F. Basi farmacologiche delle sindromi asmatico-bronchiali. Folia Allerg Immunol Clin 2, 59, 1980. 11. Dini G, Franconi F, Martini F. Mitochondrial alterations induced by selenium in guinea pig myocardium. Exp Mol Path 34, 226, 1981. 12. Franconi F, Martini F, Manghi N, Galli A, Bennardini F, Giotti A. Uptake of H3 taurine into myocardial menbranes. Biochem Pharmacol 30, 77, 1981. 13. Franconi F, Martini F, Bennardini F, Mangiapane A, Giotti A. Taurine uptake in sarcolemma vescicles isolated from hypertrophic guinea pig heart. Biochem Pharmacol 30, 693, 1981. 14. Papini M, Martinetti MG, Buffoni F, Ignesti G, Franconi F. Biochemical markers in stealy hair syndrome. Ital J Neurol Sci 2,129,1981. 15. Bandinelli R, Franconi F, Giotti A, Martini F, Moneti G, Stendardi I, Zilletti L. The positive inotropic effect of taurine and calcium and the levels of taurine in ventricular strips. Brit J Pharmacol 72, 115P, 1981. 16. Franconi F, Stendardi I, Martini F, Zilletti L, Giotti A. Interaction between organic calcium-channel blockers and taurine in vitro and in vivo. J Pharm Pharmacol 34, 329, 1982. 17. Franconi F, Giotti A, Manzini, Martini F, Stendardi I, Zilletti L. The effect of taurine on high potassium and noradrenaline induced contraction in rabbit ear artery. Brit J Pharmacol 75, 605, 1982. 18. Franconi F, Giotti A, Manzini, Martini F, Stendardi I, Zilletti L. Observation on the action of taurine at arterial and cardiac levels. In Taurine in Nutrition and Neurology, Eds. R.J. Huxtable and H. Pasantes Morales, Plenum Press, New York, p. 181, 1982 19. Franconi F, Martini F, Stendardi I, Matucci R, Zilletti L, Giotti A. Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips. Biochem Pharmacol 31, 3181, 1982. 20. Dini G, Martini F, Stendardi I, Bennardini F, Franconi F. Time-course of sodium selenite- induced ultrastructural alternations in guinea-pig hearts. Exp Mol Path.36, 326, 1982. 21. Amerini S, Franconi F, Ledda F, Mantelli L, Mugelli A.:H1 and H2 - receptor in the guinea-pig heart: and electrophysiological study. Agents Actions, 12, 131, 1982. 22. Casini A, Martini F, Nieri S, Ramarli D, Franconi F, Surrenti R. High-performance liquid chromatographic determination of hydroxyproline after derivatizzation with 4-dimenthylaminoazobenzone-4-sulphonyl chlorides. J Chromat 247, 187, 1982. 23. Dini G, Franconi F, Matucci R. Early alterations induced by sodium selenite " in vivo ". Caryol. 35, 116, 1982. 24. Dini G, Martini F, Stendardi I, Franconi F. Cytotoxic effect of sodium selenite. Caryol. 35, 133, 1982. 25. Franconi F, Manzini S, Stendardi I, Bennardini F, Antonini G, Failli P, Matucci R, Manzini S, Giotti A. Differential inhibitory effect of taurine on contractile response to potassium and noradrenaline in rabbit ear artery. J Pharm Pharmacol 35, 46, 1983. 26. Franconi F, Stendardi I, Failli P, Antonini G, Bennardini F, Matucci R, Manzini S, Giotti A. Taurine antagonizes alpha adrenergic positive inotropic effect of phenylepherine. In: Sulfur aminoacids: Biochemical and clinical Aspects, eds. K. Kuriyama, R.J. Huxtable, H. Iwata. Alan Liss, N.Y. 51, 1983. 27. Antonini G. Franconi F, Giotti A, Ledda F, Mantelli L, Stendardi I. Reoxygenation dyshrythmias in the isolated guinea-pig heart: sensitivity to prazosin, atenolol and practolol. Pharmacol Res Comm 15, 751, 1983. 28. Conte Camerino D, Franconi F, Mitolo Chieppa D, Giotti A. Effects of taurine on the electrical properties of mammalian skeletal muscle fibers. Acta Pharmacol Toxicol 53, suppl. 1, 109, 1983 29. Franconi F, Bennardini F, Stendardi I, Matucci R, Antonini G, Giotti A. Taurine: a sulphonic aminoacid modulates alpha cardiac adrenoceptors. Acta Pharmacol Toxicol 53, suppl 1, 124, 1983. 30. Franconi F, Stendardi I, Matucci R, Failli P, Bennardini F, Antonini G, Giotti A. Inotropic effect of taurine in guinea-pig ventricular strips. Eur J Pharmacol 102, 511, 1984. 31. Giotti A, Ledda F, Franconi F, Mantelli L, Mugelli A. Cardiac alpha adrenergic receptor: Do they have a role? In: Frontiers in Cardiology for the eighties, eds. L Donato, F Abbate. Raven Press Inc. London, 127, 1984. 32. Bennardini F, Amerini S, Franconi F, Ledda F, Mantelli L, Matucci R, Mugelli A, Sorbi C. On the presence of H1-receptors in various sections of guinea pig heart: a correlation between binding and functinal studies. Agents Actions, 15, 167, 1984. 33. Ignesti G, Antonini G, Bennardini F, Matucci R, Dini G, Franconi F. The effect of sodium selenite on respiratory function in mitochondria isolated from guinea pig heart. Arch. Toxicol Suppl. 7, 444, 1984. 34. Franconi F, Bennardini F, Stendardi I, Matucci R, Dini G, Giotti A. Effect of leucine methylester on guinea-pig atria. Acta Pharmacol Toxicol 57, 141, 1985. 35. Franconi F, Stendardi I, Failli P, Matucci R, Baccaro C, Montorsi L., Bandinelli R, Giotti A. The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart. Biochem Pharmacol 34, 2611, 1985. 36. Franconi F, Stendardi I, Matucci R, Bennardini F, Baccaro C, Giotti A. A protective effect of taurine in" hypoxic" and "reoxygenated" guinea-pig heart. In: Taurine: biological actions and clinical perspective, eds S Oja, L Althee, P Kontro. M. Paasonen. Alan Liss Inc. N.Y. 177, 1985. 37. Baccaro C, Failli P, Franconi F, Giotti A, Montorsi L. Cardioprotective activity in vitro of L-arginine methylester during cardiac hypoxia and reoxygenation. Brit J Pharmacol 86, 612P, 1985. 38. Bennardini F, Franconi F, Giotti A, Matucci R, Stendardi I. Binding of 3H-nitrendipine during hypoxia and subsequent reoxygenation. Brit J Pharmacol 86, 623P, 1985. 39. Bryant SH, Conte Camerino D, Franconi F, Giotti A, Mambrini M. Lack of antagonism by taurine on chloride channel block by anthracene-9-carboxylic acid in rat skeletal muscle. Brit J Pharmacol, 86, 586P, 1985. 40. Ignesti G., Antonini G., Bennardini F., Montorsi L., Dini G., Franconi F.: Effects of sodium selenite on guinea-pig cardiac isolated mitochondria. Biochem Pharmacol 35, 405, 1986. 41. Franconi F, Bennardini F, Matucci R, Stendardi I, Failli P, Manzini S, Giotti A. Functional and binding evidence of taurine inhition of alpha-adrenoreceptors effects on guinea-pig ventricle. J Mol Cell Cardiol 18, 461, 1986. 42. Baccaro C, Bennardini F, Dini G, Franconi F, Giotti A, Matucci R, Minuti P. Cardiac hypoxia and subsequent reoxygenation: sensitivy to L-arginine methylester. Brit J Pharmacol 87, 649, 1986. 43. Franconi F, Failli P, Stendardi I, Matucci R, Bennardini F, Baccaro C, Giotti A. Positive inotropic effect of some taurine-related compounds in guinea-pig ventricular strips perfused with low calcium medium. Eur J Pharmacol 124, 129-, 1986. 44. Masini E, Franconi F, Peduto AV, Pieraccioli E, Matucci R, Novelli G.P. Liver function following hypovolemic hypotension in rats anaesthetized with halotane or enflurane. Pharmacol Res Commun: 18, 847, 1986. 45. Matucci R, Bennardini F, Sciammarella ML, Baccaro C, Stendardi I, Franconi F, Giotti A. 3H-nitrendipine binding obtained from hypoxic and reoxygenated heart. Biochem Pharmacol 36,1059, 1987. 46. Huxtable RJ, Franconi F. Introduction: Biochemistry, nutrition and development. In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 25, 1987. 47. Franconi F, Huxtable RJ. Introduction: Pharmacology of excitable tissue. In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., 149, 1987. 48. Huxtable RJ, Franconi F. Introduction: Neurochemistry In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 247, 1987. 49. Franconi F, Stendardi I, Failli P, Fazzini A, Giotti A. Inotropic activity of orthanilic and L-cysteic acid on isolated guinea-pig ventricular strips. In: The Biology of Taurine: Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Plubishing Co. N.Y., pp. 159- , 1987. 50. Bennardini F, Failli P, Matucci R, Bartolini A, Morandini D, Polenzani L, Franconi F, Giotti A. Effect of taurine on excitatory receptor binding in rat hippocampal membranes. In: The Biology of Taurine: Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 325, 1987. 51. Conte-Camerino D, Franconi F, Mambrini M, Mitolo Chieppa D, Bennardini F, Failli P, Bryant SH, Giotti A. Taurine and drugs inducing myotonia in rat skeletal muscle. In: The Biology of Taurine: Methods and Mechanisms. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 207, 1987. 52. Manzini S, Castellucci A, Franconi F, Giotti A. An analysis of the effects of taurine on cellular and extracellular Ca2+ mobilzation in rabbit ear artery. In: The Biology of Taurine. Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 181, 1987. 53. Bennardini F, Failli P, Matucci R, Bartolini A, Malcangio M, Franconi F, Giotti A. L-Arginine methylester reduces L-3H glutamate binding and Ca2+ activated neutral protease activity in rat hippocampal membranes. Fund Clin Pharmacol 1, 297, 1987. 54. Conte-Camerino D, Lograno M, De Luca A, Persichella M, Franconi F. The effect of calcium channel agonist BAY K-8644 on guinea-pig ileum and rat uterine horn. J Pharm Pharmacol 39, 954, 1987. 55. Conte-Camerino D, Franconi F, Mambrini M, Bennardini F, Failli P, Bryant SH, Giotti A. The action of taurine on chloride conductance and excitability characteristics of rat striated muscle fibers. Pharmacol Res Comm 19, 685, 1987. 56. Fantozzi R, Franconi F, Rubino A, Tarli S, Brunelleschi S, Failli P, Matucci R, Giotti A. Drug modulation of oxy-radical production by human neutrophyls. In: New Perspectives in Pharmacological Sciences. Eds. F. Drago and J.M. Van Ree, Published by The Italian Pharmacological Society, pp. 81, 1987. 57. Franconi F, Baccaro C, Bennardini F, Failli P, Fazzini A, Masini M, Matucci R, Stendardi I, Giotti A. D-arginine methylester activityon guinea-pig heart during hypoxia and reoxygenation. J Mol Cell Cardiol Supp 19, S-24, 1987. 58. Franconi F, Failli P, Fazzini A, Polenzani L, Giotti A. Taurine reduces the increase in (Ca Ca2+)i due to phenylephrine in cardiac myocytes. Mol. Cell. Cardiol. 20 Supp. V, S-37, 1988. 59. Citi S, Amorosi A, Franconi F, Zampi G, Giotti A. Identification and characherization of polypeptides immunologicolhy related to cinguilin, a specifie protein component of tight junctions, in human epithelial cells. Pharmacol Res Comm 20 Supp 2, 374, 1988. 60. Franconi F, Stendardi I, Giotti A. Studies on taurine positive inotropic effect in guinea-pig ventricular strips. Pharmacol Res Comm 20 Supp. I, 93, 1988. 61. Malcangio M, Bartolini A, Ghelardini C, Bennardini F, Malberg-Aiello P, Franconi F, Giotti A. Effect of I.C.V. taurine on the impairment of learning, convulsion and death caused by hypoxia. Psycopharmacol 98, 316, 1989. 62. Franconi F, Failli P, Bennardini F, Matucci R, Fazzini A, Stendardi I, Giotti A. Taurine's modulation of inotropism in guinea pig heart. Sulfur amino acids. In: Taurine and the heart. Iwata H, Lombardini JB, Segawa I, eds. Kluwer Acad. Press., 21, 1989. 63. Conte-Camerino D, De Luca A, Mambrini M, Ferrannini E, Franconi F, Giotti A, Bryant SH. The effect of taurine on pharmacologically induced myotonia. Muscle Nerve 12, 898, 1989. 64. Seghieri G, Bartolomei GC, De Giorgio LA, Innocenti F, Gironi A, Mian M, Franconi F. Serum digoxin and Beta-methyldigoxin in elderly patients on hospital admission: correlation with home compliance and clinical variables. Eur J Clin Pharmacol.37, 401, 1989. 65. De Luca A, Conte-Camerino D, Failli P, Franconi F, Giotti A Effects of taurine on mammalian skeletal muscle fiber during development. Prog Clin Biol Res 351, 163-73, 1990. 66. Franconi F, Bennardini F, Campana S, Failli P, Matucci R, Stendardi I, Giotti A. Effect of taurine L-cysteic and orthanilic acids on cardiac tension. Prog Clin Biol Res 351, 175, 1990. 67. Franconi F, Matucci R, Ottaviani F, Bianchi B, Giotti A. Carbon center radicals are involved in the regulation of L-type Ca2+ channels. Pharmacol Res 22: Supp 2, 217, 1990. 68. Baccaro C, Brunori M, Di Simplicio P, Fazzini A, Franconi F, Giotti A. Effect of cumene-hyodroperoxide or hypoxia-reoxygenation on gluthatione status in guinea-pig heart. Biochem Pharmacol 39, 1617, 1990. 69. Mattana A, Franconi F, Manca P, Juliano C, Cappuccinelli P. A cytotoxic effect of H2O2 trichomonas vaginalis may be correlated to cytoskleton modification. Pharmacol Res 22 Supp. 4 76, 1990. 70. Franconi F, Matucci R, Ottaviani F, Bianchi B, Fazzini A, Giotti A. Effect of non enzymatic radical generation on L-type calcium channel. Eur J Pharmacol 183, 1658, 1990. 71. Naro F, Fazzini A, Citro G, Malatesta F, Antonini G, Sarti P, Brunori M, Franconi F, Giotti A. Immuno quantitation of cytochrome c in cardiac perfusate J Immunoassay 12, 251, 1991. 72. Citi S, Amorosi A, Franconi F, Giotti A, Zampi GC: Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues. Am J Pathol. 138, 781, 1991. 73. Franconi F, Failli P. Cardiac toxicology of cardiac depressant: principles of cardiotoxicology. Ed. S.I. Baskin, Telford Press Cadwell Boca Raton, p. 521, 1991. 74. Seghieri G, Gironi A, Mannini P, Alviggi L, De Giorgio LA, Bartolomei G.C., Ignesti G., Franconi F. Erythrocyte spermidine levels in IDDM patients Diabetes Cares, 15, 543, 1992. 75. Franconi F, Miceli M, Bennardini F, Mattana A, Covarrubias J, Seghieri G: Taurine potentiates the antiaggregatory action of aspirin and indomethacin. In Taurine Nutritional Value and Mechanism of action Eds JB Lombardini, SW Schaffer, J Azuma, Plenum Press N.Y. London, 181, 1992. 76. De Luca A, Pierno S, Huxtable RJ, Failli P, Franconi F, Giotti A, Conte-Camerino D. Effects of taurine depletation on membrane electrical properties of rat skeletal muscle. In Taurine Nutritional Value and Mechanism of action. Eds. JB Lombardini, SW Schaffer, J Azuma, Plenum Press, 199,1992. 77. Matucci R, Ottaviani MF, Campana S, Bianchi B, Bennardini F, Moneti G, Giotti A, Franconi F. Do ethoxy Radical Reduce 3H nitrendipine binding in rat cardiac membranes. Pharmacol Res Comm 26, 151, 1992. 78. Bennardini F, Meloni M, Sciola L, Spano A, Ganadu ML, Naldini L, Franconi F, Pippia P. Investigation on the antiproliferative activity of copper-cimetidine derivatives in neoplastic and syngeneic normal cells: role of H2-receptors. Ital J Biochem 41:,118A, 1992. 79. Bennardini F, Mattana A, Sciola L, Pippia P, Franconi F, Chiesi M. αB crystallin is not expressed in tumor cells derived from rat fibroblasts. Pharmacol Res 26: Suppl. 1, 67, 1992. 80. Miceli M, Bennardini F, Mattana A, Covarrubias J, Seghieri G, Franconi F. Taurine modifies platelet sensitivity to aspirin, indomethacin, sodium nitroprusside and papaverine. Platelets 3, 265, 1992. 81. Mattana A, Juliano C, Bennardini F, Mignano M, Marceddu S, Picci V, Di Simplicio P, Franconi F. Hydrogen peroxide-induced cytotoxicity in cultured epithelial cell (WISH): a functional and morphological study. Toxicol in Vitro 6, 533, 1992. 82. Failli P, Fazzini A, Franconi F, Stendardi I, Giotti A. Taurine antagonizes the increase in intracellular calcium concentration induced by α-adrenergic stimulation in freshly isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol 24, 1253, 1992. 83. Martinoli L, Di Felice M, Seghieri G, Ciuti M, Di Giorgio LA, Fazzini A, Gori R, Anichini R, Franconi F. Plasma retinol and -tocopherol concentrations in insulin-dependent diabetes mellitus: their relationship to microvascular complications. Internal J Vit Nutr Res 63, 87, 1993. 84. Naro F, Fazzini A, Grappone C, Citro G, Dini G, Giotti A, Malatesta F, Franconi F, Brunori M. Release of cytochromes from hypoxic and reoxygenated guinea pig heart. Cardioscience 4, 177, 1993. 85. Seghieri G, Martinoli L, Di Felice M, Anichini R, Bennardini F, Gori R, Bartolomei GC, Franconi F. Plasma levels of retinol and of α-tocopherol in non-insulin dependent diabetes mellitus: its relation with micro- or macroangiopathy. Diab Nutr Metab 6, 207, 1993. 86. Mattana A, Juliano C, Picci V, Franconi F, Capuccinelli P. Enhancement of the antimicrobial activity of 5-nitroimidazole derivates by hydrogen peroxide. Microbiologica 16, 359, 1993. 87. Bennardini F, Mattana A, Franconi F, Sciola L, Pippia P, Chiesi M. Changes of the αB crystallin solubility properties in fibroblasts and sarcoma Galliera cells. It J Biochem 42, 284, 1993. 88. Seghieri G, Martinoli L, Miceli M, Ciuti M, D'Alessandri G, Gironi A, Palmieri L, Anichini R, Bartolomei CG, Franconi F. Renal excretion of ascorbic acid in insulin dependent diabetes mellitus. Internat J Vit Nutr Res 64,119, 1994 89. Mattana A, Bennardini F, Juliano C, Picci V, Marceddu S, Sciola L, Pippia P, Franconi F. Cytotoxicity of lazaroid U-75412E in human epithelial cell line (WISH). Biochem Pharmacol 48, 259, 1994. 90. Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Bartolomei GC, Anichini R, Seghieri G. Taurine level in plasma and platelets in insulin-dependent and non-insulin-dependent diabetes mellitus: correlation with platelet aggregation. In Taurine in Health and Diseases, eds, R.J. Huxtable, D. Michalk, Plenum Press. New York, pag. 419, 1994. 91. Ferrarini PL, Mori C, Miceli M, Franconi F. Synthesis of antiplatelet activity of some 1,8-Naphthyridine derivates. Eur Med Chem 29, 735, 1994. 92. Seghieri G, Miceli M, Bennardini F, Ciuti M, Gironi A, Annichini R, Bartolomei GC, Franconi F. Taurine levels in plasma and platelets in insulin-dependent diabetes mellitus: relationship with platelet aggregation. In Diabetes eds S. Baba, T. Kaneko, Elsevier, Amsterdam pag. 1087, 1995. 93. De Simplicio P, De Giorgio LA, Cardaioli E, Lecis R, Miceli M, Rossi R, Annichini R, Mian M Franconi F. Glutathione, glutatione enzyme and thioltransferase in platelet of insulin-dependent diabetic patients: relation with aggregation and with microangiopathic complications. Eur J Clin Inv 25, 665, 1995. 94. Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Bartolomei GC, Anichini R, Seghieri G. Taurine deficiency in plasma and platelets of diabetic insulin-dependent patients: effects of taurine supplementation. Am J Clin Nutr 61, 1115, 1995. 95. Bennardini F, Juliano C, Benetti D, Mian M, Chiesi M, Mattana A, Franconi F.αB crystallin is constitutively expressed in cultures of bovine chondrocytes. Biochem Biophys Res Comm 208, 742, 1995. 96. Tadolini B, Pintus G, Pinna GG, Bennardini F, Franconi F. Effect of taurine and hypotaurine on lipid peroxidation. Biochem Biophys Res Comm 213, 820, 1995. 97. Bennardini F, Mattana A,. Pinna Nossai E,. Mignano M, Franconi F, Juliano C, Sciola L, Pippia P, Chiesi M. Kinetic changes of B crystallin expression in neoplastic cells and in syngenic rat fibroblast at various subculture stage. Mol Cell Biochem 152, 23, 1995. 98. Ignesti G, Gironi A, Massari M, Panichi V, Matucci R,. Miceli M, Franconi F, Seghieri G. Serum Albumin Peroxidase activity in insulin dependent Diabetes Mellitus. Diabetes Nutr Met 8, 276, 1995. 99. Dal Piaz V, Ciciani G, Giovannoni MP, Franconi F. Synthesis and evaluation as platelet aggregation inhibitors of 6-phenyl-2,4-substituted - 3(2H)-pyridazinones and their rigid analogues benzo(h) cinnolin-3,5-diones. Drug Design Discovery 14, 53, 1996. 100. Franconi F, Miceli M, De Montis MG, Lupis-Grisafi E, Bennardini F, Tagliamonte A. NMDA receptors play an antiaggreganting role in human platelets. Thromb Haemost 76, 84, 1996. 101. Matucci R, Bianchi B, Ottaviani MF, Campana S, Bennardini F, Franconi F. Carbon centered radicals reduce the density of L-type calcium channels in rat cardiac membranes. Biochem Biophys Res Comm 223, 85, 1996. 102. Franconi F, Miceli M, Fazzini A, Seghieri G, Caputo S, Di Leo MAS, Lepore D, Ghirlanda G. Taurine and diabetes: humans and experimental models. Taurine: basic and clinical aspects. Eds. R. Huxtable, J. Azuma, M. Nakagawa, K. Kyriyama, A. Baba Plenum, 223, 85, 1996. 103. Seghieri G, Anichini R, Ciuti M, Gironi A, Bennardini F, Franconi F. Raised erytrocyte polyamine levels in non insulin dependent diabetes mellitus with great desease and albuminuria. Diab Res Clin Pract 37, 15, 1997. 104. Mattana A, Bennardini F, Usai S, Fiori PL, Franconi F, Cappuccinelli P. Acanthanoeba Castellani metabolites increase the intracellular calcium levels and cause cytotoxicity in Wish cells. Microb Pathogenesisis 23, 85, 1997. 105. Franconi F, Miceli M, Alberti L, Seghieri G, De Montis MG, Tagliamonte A. Further insights into antiaggreganting activity of NMDA in human platelets. Brit J Pharmacol 124, 35, 1998. 106. Seghieri G, Martinoli L, de Felice M, Anichini R, Fazzini A, Ciuti M, Miceli M, Gaspa L, Franconi F Plasma and platelet ascorbate pools and lipid peroxidation in insulin depedent diabetes mellitus Eur J Clin Inv 28,6 59,1998 107. Tadolini B, Franconi F. Carvedilol inhibition of lipid peroxidation. a new antioxidative mechanism Free Rad Res 29, 377, 1998 108. Napoli C, Cicala C, D’Armiento FP, Roviezzo F, Di Somma P, de Nigris F, Zuliani P, Aleotti L, Casini A, Franconi F, Cirino G. Beneficial effects of ACE-inhibition with Zofenopril on plaque formation and low-density lipoprotein oxidation in Watanabe hyperlipidemic rabbits. Gen Pharmacol 33, 467, 1999. 109. Tadolini B, Juliano C, Piu L, Franconi F, Cabrini L. Resveratrol inhibition of lipid peroxidation. Free Rad Res 33, 105, 2000. 110. Brambilla G, Cenci T, Franconi F, Galarini R, Chem, Magri A, Rondoni F, Strozzi M, Loizzo A. Clinical and pharmacological aspects in a clenbuterol epidemic poisoning from contaminated beef meat in Italy. Toxicol Lett 114, 47, 2000 111. Napoli C, Cicala C, Wallace JL, de Nigris F, Santagada V, Caliendo G, Franconi F, Ignarrro L, Cirino G. Protease-activated receptor -2 modulation of myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA 97, 3678, 2000. 112. de Nigris F, Youssef T, Ciafre AS, Franconi F, Anania V, Condorelli GL, Palinski W, Napoli C. Evidence of oxidative stress of c-Myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits Circulation 102, 2111, 2000 113. de Nigris F, Franconi F, Maida I, Anania V, Palumbo G, Napoli C. Modulation by - and -tochopherol and oxidized low density lipoprotein in human coronaric smooth muscle cells. Biochem Pharmacol 59, 1477, 2000 114. Seghieri G, Di Semplicio P, De Giorgio LA, Anichini R, Alberti L, Franconi F. Relationship of metabolic control and platelet content of glutathione, and its related enzymes, in insulin-depedent diabetes mellitus. Clin Chim Acta 299, 109, 2000 115. Ferrarini PL, Mori C, Badawneh M, Franconi F, Manera C, Miceli M, Saccomanni G. Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives. Farmaco 55, 603, 2000 116. Ferrarini PL, Badawneh M, Franconi F, Manera C, Miceli M, Mori C, Saccomanni G. Synthesis and antiplatelet activity of some 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives. Farmaco 56, 311, 2001 117. Franconi F, Miceli M, Alberti L, Boatto G, Coinu R, De Montis MG, Tagliamonte A. Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. Thromb Res 102, 255, 2001 118. Seghieri G, Di Simplicio P, Anichini R, Alviggi L, De Bellis A, Bennardini F, Franconi F. Platelet antioxidant enzymes in insulin-dependent diabetes mellitus. Clin Chim Acta 309, 19, 2001. 119. Seghieri G, Moruzzo D, Fascetti S, Bambini C, Anichini R, DeBellis A, Alviggi L, F Franconi. Increase in serum uric acid is selectively associated with stroke in Type 2 diabetes. Diabetes Care 25, 1095 2002 120. Seghieri G, Anichini R, De Bellis, A, Alviggi, F Franconi, Breschi MC: Relationship between gestational diabetes mellitus and low maternal birth weight. Diabetes Care 25, 1761, 2002 121. Di Leo MAS, Santini SA, Cercone S, Lepore D, Gentiloni Silveri N, Caputo S, Greco AV, Giardina B, Franconi F, Ghirlanda G Chronic taurine supplementation ameliorates oxidative stress and Na+K+ATPase impairment in the retina of diabetic rats Amino Acid 23, 401, 2002. 122. Di Leo MAS,. Santini SA, Gentiloni Silveri N, Giardina B, Franconi F, Ghirlanda G. Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations. Free Rad Res 37, 323, 2003 123. Seghieri G, Breschi MC, Anichini R, De Bellis A, Alviggi L, Maida I, Franconi F. Serum homocysteine levels are increased in women with gestational diabetes mellitus. Metabolism 52, 720, 2003. 124. Zoroddu MA, Grepioni F, Franconi F. Carvedilol, a α β adrenoceptor blockers with chelanting properties. A copper “Superdimer” based on dimetal units. J Inorg Biochem 95, 315, 2003. 125. Franconi F, Ghirlanda G, Santini SA, Gentiloni Silveri N, Giardina B, Di Leo MAS. Taurine reduces mortality in diabetic rats: taurine and experimental diabetes mellitus. Adv Exp Med Biol. 526, 67, 2003. 126. Miceli M, Alberti L, Bennardini F, De Semplicio P, Seghieri G, Rao G, Franconi F. Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers Life Sciences 73, 1557, 2003. 127. Seghieri G, Bardini G, Fascetti S, Moruzzo D, Franconi F. Stroke is related to lower serum thyrotropin levels in patients with diabetes mellitus Diabetes Res Clin Pract 30, 1, 2003. 128. De Simplicio P, Franconi F, Frosali S, Di Giuseppe D. Thiolation and nitrosation of cysteines in biological fluids and cells Amino Acids. 25, 323, 2003 129. Franconi F, Di Leo MAS, Bennardini F, Ghirlanda G. Is taurine beneficial in reducing risk factors for diabetes mellitus? Neurochem Res 29, 143, 2004 130. Romani A, Coinu R, Carta S, Pinelli P, Galardi C, Vincieri FF, Franconi F. Evaluation of antioxidant effect of different extracts of Myrtus communis L. Free Radic Res 38, 97, 2004. 131. Franconi F, Diana G, Fortuna A, Galietta G, Seghieri G, Trombetta G, Valentini G, Loizzo A. Taurine administration during lactation modifies hippocampal ca1 neurotransmission and behavioural programming in adult male mice. Brain Bull Res 63, 491, 2004. 132. Di Leo MAS, Santini SA, Gentiloni Silveri N, Giardina B, Franconi F, Ghirlanda G. Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats Amino Acids 27, 187, 2004. 133. Romani A, Coinu R, Lapucci C, Pinelli P, Vignolini P, Di Simplicio P, Franconi F. Minor Polar compunds of Italian virgin oil inhibit LDL oxidation and platelet reactivity Polyphenol Communications 369, 2004. 134. Turchetti B, Pinelli P, Buzzini P, Romani A, Heimler D, Franconi F. In vitro antimycotic activity of galloyl-derivates extracted from leaves of Camelia Sinensis towards yeast and yeast like strains Polyphenol Communications 415- 2004. 135. Turchetti B, Pinelli P, Buzzini P, Romani A, Heimler D, F Franconi, Martini A. In vitro antimycotic activity of some plant extracts towards yeast and yeast like strains. Phyt Res 19, 44, 2005. 136. Seghieri G, De Bellis A, Anichini R, Alviggi L, Franconi F. Breschi MC. Does parity increase insulin resistance during pregnancy ? Diab Med 22, 1574, 2005. 137. Loizzo A, Loizzo S, Galietta G, Caiola S, Spampinato S, Campana G, Seghieri G,. Ghirlanda G, Franconi F.. Overweight, and metabolic and hormonal parameters disruption, are induced in adult male mice by manipulations during lactation period. Ped Res 59, 111, 2006. 138. Franconi F, A. Loizzo, G. Ghirlanda, Seghieri. G. Taurine supplementation in diabetes mellitus. Curr Opin Clin Nutr Metab Care 9, 32, 2006. 139. Coinu R, Chiavello A, Galleri G, Franconi F, Crescenzi E, Palumbo G. Exposure to modeled microgravity induces metabolic idleness in malignant human MCF-7 and normal murine VSMC cells. FEBS Lett. 580, 2465, 2006. 140. Franconi F, Coinu R, Carta S, Urgheghe PP, Ieri F, Mulinacci N, Romani A. The antioxidant effect of two virgin olive oils depends on the concentration and composition of minor polar compounds. Food Agr Chem 54: 3121, 2006. 141. Galietta G, Loizzo A, Loizzo S, Trombetta G, Spampinato S, Campana G, Capasso A, Palermo M, Guarino I, Franconi F. Pro-opiomelanocortin antisense administration prevents enduring hormonal alterations induced by neonatal handling in male mice. Eur J Pharmacol 550, 180, 2006. 142. Seghieri G, Tesi F, Bianchi L, Loizzo A, Saccomanni G, Ghirlada G, and Franconi F Taurine in women with a history of gestational diabetes. Diab Res Clin Pract 76:187-92, 2007 143. Franconi F, Brunelleschi S, Steardo L, Cuomo G. Gender differences in drug rensponSes. Pharmacol Res 55, 81, 2007. 144. Coinu R, Carta S, Urgheghe PP, Mulinacci N, Pinelli P, Franconi F, Romani A. Dose–Effect study on the antioxidant properties of leaves and outer bracts of extracts obtained from Violetto di Toscana artichoke. Food Chem 101, 524, 2007. 145. Franconi F, Di Leo MAS, Seghieri G, Urgeghe PP, Coinu R, Di Simplicio, P Ghirlanda G Vitamin E cocktails and their preventive effects on the retina in diabetes I in "The Encyclopedia of vitamin E" Eds VR Preedy and Watson RR Cabi Publishing Wallingford (GK) pag 447, 2007 146. Franconi F, Carru C, Canu S, Seghieri G. Targeting gender difference in the introduction of new drugs for diabetes mellitus and metabolic disorders. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 1, 152, 2007. 147. Loizzo A, Bennardini F, Coinu R, Carta S, Loizzo S, Guarino I, Seghieri G, Ghirlanda G, Franconi F. Neonatal taurine administration modifies metabolic programming in male mice. Early Human Develop 83: 693, 2007 148. Straface E, Vona R, Ascione B, Matarrese P, Strudthoff T, Franconi F, Malorni W Single exposure of human fibroblasts (WI-38) to a sub-cytotoxic dose of UVB induces premature senescence FEBS Lett 581:4342, 2007 149. Malorni W, Campasi I, Straface E, Vella S, Franconi F. Redox features of the cell: a gender perspective. Antioxidants & Redox Signaling 9:1779, 2007 150. Brunelleschi S, Bardelli C, Amoroso A, Gunella; Ieri F, Romani A, Malorni W, Franconi F. Olive oil: from Mediterranean diet to NF-κB inhibition. Pharmacol Res 56: 542-9 2007 151. Priora F, Summa D, Frosali S, Margaritis A, Di Giuseppe D, Lapucci C, Ieri F, Pulcinelli FM, Franconi F, Di Simplicio P. Administration of minor polar compound enriched-extra virgin olive oil decreases platelet aggregation and the plasma concentrations of the reduced-homocysteine in rats J Nutr 138:36-41. 2008 152. Seghieri G, Tesi F, Anichini R, De Bellis A, Fabbri G, Malagoli R, Franconi F. Gender modulates the relationship between body weight and plasma glucose in overweight or obese subjects. Diabetes Res Clin Pract 80, 134-138, 2008 153. Franconi F, Seghieri G, Canu S, Straface E, Campesi I, , Malorni W. Are the available experimental models of type 2 diabetes appropriate for a gender perspective? Pharmacol Res 57, 6-18, 2008 154. Malorni W, Straface E, Matarrese P, Ascione B, Coinu R, Canu S, Galluzzo P, Marino M, Franconi F Redox state and gender differences in vascular smooth muscle cells. FEBS lett 582, 635-42, 2008 155. Sotgia S, Carru C, Franconi F, Fiori PB, Manca S, Pettinato S, Magliona S Ginanneschi R, Deiana L, Zinellu A Rapid quantification of total genomic DNA methylation degree by short-end injection capillary zone electrophoresis. J Chromatogr A.1185:145-50, 2008 156. Ortona E, MatarreseP, Margutti P, Franconi F, Malorni W. Redox state, cell death and autoimmune diseases: A gender perspective. Autoimmun Rev 7:579-84. 2008 157. Maselli A, Matarrese P, Straface E, Canu S, Franconi F, Malorni W. Cell sex: a new task for cell fate studies? Faseb J 23: 978-84. 2009 158. Zinellu A, Sotgia S, Scanu B, Chessa R, Gaspa L, Franconi F, Deiana L, Carru C. Taurine determination by capillary electrophoresis with laser induced fluorescence detection: From clinical field to quality food applications. Amino Acid 36:35-41. 2009 159. Pinna A, Zinellu A, Franconi F, Solinas G, Carru C. Plasma Cysteinylglycine and Taurine Levels are Reduced in Branch Retinal Vein Occlusion Ophthalmic Res. 43:26-32, 2009 160. Straface E, Gambardella L, Vona R, Ascione B, Marino M, Bulzomi P, Coinu R, Canu S, Malorni W, Matarrese P, Malorni W Franconi F Cell sex determines anoikis resistance in vascular smooth muscle cells FEBS lett 583, 3348-54 161. D'Aquila PS, Canu S, Sardella M; Spanu C, Serra G, Franconi F Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats. Behavioural Pharmacology in press 162. Musino L, Rossi R, Partenza A, Mureddu G, Zinellu A, Pilo P, Maoddi I, Spazzafumo L, Franconi F, Deiana L, Carru C. Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. Front Biosci (Elite Ed). 2010 Jan 1;2:559-65. 163. Loizzo S, Vella S, Fortuna A, Frajese GV, Agrapart V, Morales RR, Spampanato S, Campana G, Papasso A, Galletta G, Guarino I, Carta S, Carru C, Zinellu A, Ghirlanda G, Seghieri G, Renzi P, Franconi F Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary metabolic syndrome model in mice depends on HPA hormones . submitted [b]Brevetti:[/b] 1. Numero Fi 2005°000219 depositato il 20/10/2005 2. (WO/2007/046125) USE OF EXTRACTS OF MYRTLE AND OTHER MEDITERRANEAN ... 3. “oligonucleotidi antisenso anti pro-opiomelanocortina ipofisiaria e loro uso in campo medico per la prevenzione e la terapia della sindrome post-traumatica da stress (ptsd)” RM2007A00005 depositato il 05/01/07 [b] Capitoli e libri italiani: [/b] 1. Giotti A, Zilletti L, Franconi F. Agonisti e antagonisti adrenergici nella terapia dello shock: considerazioni sulle basi farmacologiche del loro impiego. In: Basi razionali della terapia dello shock, Eds. R. Vecchioni, C. Cordiano. Piccin Editori, Padova 68, 1978. 2. Giotti A, Franconi F, Zilletti L. Regolazione del processo coagulativo da parte della parete vasale. In: Problemi farmacologici nei disordini secondari dell'emostasi. Eds. E Antonini, A Doni e E Genazzani, La Giuntina, Firenze, 33, 1978. 3. Franconi F, Blandina P. Noradrenalina, X Volume Enciclopedia Medica Italiana, USES, Roma, p. 1233, 1983. 4. Franconi F. Prazosin. In Trattato di Farmacologia e Chemioterapia, II Volume. Eds. E Gennazzani, A Giotti, P Mantegazza, G Pepeu, P Periti. USES, Roma, p. 424, 1983. 5. Franconi F. Minossidile. In Trattato di Farmacologia e Chemioterapia. II Volume. Eds. E Gennazzani, A Giotti, P Mantegazza, G Pepeu, P Periti. USES, Roma, p. 325, 1983. 6. Franconi F.: Atenololo. In Trattato di Farmacologia e Chemioterapia. II Volume. Eds. E Gennazzani, A Giotti, P Mantegazza, G Pepeu, P Periti USES, Roma, p. 43, 1983. 7. Franconi F.: Etacrinico acido. In Trattato di Farmacologia e Chemioterapia. II Volume. Eds. E Gennazzani, A Giotti, P Mantegazza, G Pepeu, P Periti. USES, Roma, p. 215, 1983. 8. Franconi F.: Diazossido. In Trattato di Farmacologia e Chemioterapia. II Volume. Eds. E Gennazzani, A Giotti, P Mantegazza, G Pepeu, P Periti. USES, Roma, p. 170, 1983. 9. Franconi F., Blandina P. Lo Strofanto. Enciclopedia Medica Italiana, Vol. XIV, 1451, 1987. 10. Franconi F, Fazzini A, Polenzani L. Soluzioni fisiologiche per organi isolati.In Farmacologia e Tossicologia Sperimentale, Eds. Dolara P, Franconi F, Mugelli A, Editrice Pitagora Bologna, 113, 1989. 11. Matucci R, Franconi F. Preparazione e frazionamento dei componenti subcellulari. In Farmacologia e Tossicologia Sperimentale, Eds. Dolara P, Franconi F, Mugelli A, Editrice Pitagora, Bologna, 65, 1989. 12. Flavia Franconi “Neurofarmacologia e neuroprotezione “Neurologia e Donna” 2007 Elleboro Torino 13. Franconi F e Allais GB Interazioni farmacologiche nel trattamento dell’emicrania Pacini- editore, Pisa 2007 14. Motilla S, Folino-Gallo P, Franconi F, Farmaci e Donne ONDA 2008 in press 15. Flavia Franconi La medicina di genere e le iniziative italiane in Stress lavoro-correlato e ottica di genere : due sfide per il “Testo Unico” Verso l’elaborazione di linee guida in press [b] Articoli divulgativi: [/b] Franconi F. Una Cenerentola: la Farmacologia di Genere Monitor 12, 63, 2004 Romani A., Lapucci C., Priora R., Di Simplicio P., Franconi F., Cresti G. “Olio extra vergine di oliva toscano: caratteristiche chimiche, stabilità e valutazione delle proprietà salutistiche”. Pag. 18-25, in “C'è Olio e … Olio in Toscana”. A cura di Andrea Zanfi. Carlo Cambi editore. 2005 Franconi F. La Cenerentola sta entrando in società PNEI 2,13, 2007 Franconi F, I. Ceserani, M.E. Scamoni SIF e Genere Quaderni della SIF 13, 20, 2008 Franconi F, Campesi I Farmacologia di genere. Società Italiana di Medicina Generale 3, 345, 2008 [b]Rapporti Istituzionali: [/b] Raccomandazioni mediche per la donna in menopausa Agenzia Servizi Sanitari Regionali Lo Stato della Salute delle Donne in Italia Ministero della Salute 2008
Pubblicazioni & Link
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Inibitori della prosta-glandino-sintetasi e fenomeni anafilattici. Folia Allerg Immunol Clin 22, 293, 1975 | Leggi il contenuto
Hypertonic sodium chloride and lidocaine in a case of impramine intoxication. Clin Toxicol 10, 395, 1977. | Leggi il contenuto
The effect of phalloidin on natural and U.V. denaturated bovine serum albumin. Pharmacol Res Comm 9, 339, 1977. | Leggi il contenuto
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Effect of taurine on calcium inotropism and electrical activity of the heart. In: Taurine and neurological disorders, Eds A. Barbeau, R.J. Huxtable, Raven Press.,N.Y., 151, 1978 | Leggi il contenuto
Taurine calcium interaction measured by means of 13C nuclear magnetic resonance. Biochem. Pharmacol. 27, 803, 1978 | Leggi il contenuto
Effect of selenium on the contractile force of isolated and perfused guinea-pig heart. Acta Pharmacol. Toxicol. 46, 98, 1980 | Leggi il contenuto
Modulazione adrenergica della broncoreattività, correlazioni farmacologiche cliniche. Folia Allerg Immunol. Clin 27, 1, 1980 | Leggi il contenuto
Basi farmacologiche delle sindromi asmatico-bronchiali. Folia Allerg Immunol Clin 2, 59, 1980 | Leggi il contenuto
Mitochondrial alterations induced by selenium in guinea pig myocardium. Exp Mol Path 34, 226, 1981 | Leggi il contenuto
Uptake of H3 taurine into myocardial menbranes. Biochem Pharmacol 30, 77, 1981 | Leggi il contenuto
Taurine uptake in sarcolemma vescicles isolated from hypertrophic guinea pig heart. Biochem Pharmacol 30, 693, 1981 | Leggi il contenuto
Biochemical markers in stealy hair syndrome. Ital J Neurol Sci 2,129,1981 | Leggi il contenuto
The positive inotropic effect of taurine and calcium and the levels of taurine in ventricular strips. Brit J Pharmacol 72, 115P, 1981 | Leggi il contenuto
Interaction between organic calcium-channel blockers and taurine in vitro and in vivo. J Pharm Pharmacol 34, 329, 1982 | Leggi il contenuto
The effect of taurine on high potassium and noradrenaline induced contraction in rabbit ear artery. Brit J Pharmacol 75, 605, 1982 | Leggi il contenuto
Observation on the action of taurine at arterial and cardiac levels. In Taurine in Nutrition and Neurology, Eds. R.J. Huxtable and H. Pasantes Morales, Plenum Press, New York, p. 181, 1982 | Leggi il contenuto
Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips. Biochem Pharmacol 31, 3181, 1982 | Leggi il contenuto
Time-course of sodium selenite- induced ultrastructural alternations in guinea-pig hearts. Exp Mol Path.36, 326, 1982 | Leggi il contenuto
H1 and H2 - receptor in the guinea-pig heart: and electrophysiological study. Agents Actions, 12, 131, 1982 | Leggi il contenuto
High-performance liquid chromatographic determination of hydroxyproline after derivatizzation with 4-dimenthylaminoazobenzone-4-sulphonyl chlorides. J Chromat 247, 187, 1982 | Leggi il contenuto
Early alterations induced by sodium selenite " in vivo ". Caryol. 35, 116, 1982 | Leggi il contenuto
Cytotoxic effect of sodium selenite. Caryol. 35, 133, 1982 | Leggi il contenuto
Differential inhibitory effect of taurine on contractile response to potassium and noradrenaline in rabbit ear artery. J Pharm Pharmacol 35, 46, 1983 | Leggi il contenuto
Taurine antagonizes alpha adrenergic positive inotropic effect of phenylepherine. In: Sulfur aminoacids: Biochemical and clinical Aspects, eds. K. Kuriyama, R.J. Huxtable, H. Iwata. Alan Liss, N.Y. 51 | Leggi il contenuto
Reoxygenation dyshrythmias in the isolated guinea-pig heart: sensitivity to prazosin, atenolol and practolol. Pharmacol Res Comm 15, 751, 1983 | Leggi il contenuto
Effects of taurine on the electrical properties of mammalian skeletal muscle fibers. Acta Pharmacol Toxicol 53, suppl. 1, 109, 19 | Leggi il contenuto
Taurine: a sulphonic aminoacid modulates alpha cardiac adrenoceptors. Acta Pharmacol Toxicol 53, suppl 1, 124, 1983 | Leggi il contenuto
Inotropic effect of taurine in guinea-pig ventricular strips. Eur J Pharmacol 102, 511, 1984 | Leggi il contenuto
Cardiac alpha adrenergic receptor: Do they have a role? In: Frontiers in Cardiology for the eighties, eds. L Donato, F Abbate. Raven Press Inc. London, 127, 1984 | Leggi il contenuto
On the presence of H1-receptors in various sections of guinea pig heart: a correlation between binding and functinal studies. Agents Actions, 15, 167, 1984 | Leggi il contenuto
The effect of sodium selenite on respiratory function in mitochondria isolated from guinea pig heart. Arch. Toxicol Suppl. 7, 444, 1984 | Leggi il contenuto
Effect of leucine methylester on guinea-pig atria. Acta Pharmacol Toxicol 57, 141, 1985 | Leggi il contenuto
Bandinelli R, Giotti A. The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart. Biochem Pharmacol 34,  | Leggi il contenuto
A protective effect of taurine in" hypoxic" and "reoxygenated" guinea-pig heart. In: Taurine: biological actions and clinical perspective, eds S Oja, L Althee, P Kontro. M. Paasonen. Alan Liss Inc. N. | Leggi il contenuto
Cardioprotective activity in vitro of L-arginine methylester during cardiac hypoxia and reoxygenation. Brit J Pharmacol 86, 612P, 1985 | Leggi il contenuto
Binding of 3H-nitrendipine during hypoxia and subsequent reoxygenation. Brit J Pharmacol 86, 623P, 1985 | Leggi il contenuto
Lack of antagonism by taurine on chloride channel block by anthracene-9-carboxylic acid in rat skeletal muscle. Brit J Pharmacol, 86, 586P, 1985 | Leggi il contenuto
Effects of sodium selenite on guinea-pig cardiac isolated mitochondria. Biochem Pharmacol 35, 405, 1986 | Leggi il contenuto
Functional and binding evidence of taurine inhition of alpha-adrenoreceptors effects on guinea-pig ventricle. J Mol Cell Cardiol 18, 461, 1986 | Leggi il contenuto
Cardiac hypoxia and subsequent reoxygenation: sensitivy to L-arginine methylester. Brit J Pharmacol 87, 649, 1986 | Leggi il contenuto
Positive inotropic effect of some taurine-related compounds in guinea-pig ventricular strips perfused with low calcium medium. Eur J Pharmacol 124, 129-, 1986 | Leggi il contenuto
Liver function following hypovolemic hypotension in rats anaesthetized with halotane or enflurane. Pharmacol Res Commun: 18, 847, 1986 | Leggi il contenuto
3H-nitrendipine binding obtained from hypoxic and reoxygenated heart. Biochem Pharmacol 36,1059, 1987 | Leggi il contenuto
Introduction: Biochemistry, nutrition and development. In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 25, 1987 | Leggi il contenuto
Introduction: Pharmacology of excitable tissue. In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., 149, 1987 | Leggi il contenuto
Introduction: Neurochemistry In: The Biology of Taurine: Methods and Mechanism. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 247, 1987 | Leggi il contenuto
Inotropic activity of orthanilic and L-cysteic acid on isolated guinea-pig ventricular strips. In: The Biology of Taurine: Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Plubish | Leggi il contenuto
Effect of taurine on excitatory receptor binding in rat hippocampal membranes. In: The Biology of Taurine: Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., p | Leggi il contenuto
Taurine and drugs inducing myotonia in rat skeletal muscle. In: The Biology of Taurine: Methods and Mechanisms. Giotti A, Franconi F, Huxtable RJ Plenum Publishing Co., N.Y., pp. 207, 1987 | Leggi il contenuto
An analysis of the effects of taurine on cellular and extracellular Ca2+ mobilzation in rabbit ear artery. In: The Biology of Taurine. Methods and Mechanisms. Eds. Giotti A, Franconi F, Huxtable RJ Pl | Leggi il contenuto
L-Arginine methylester reduces L-3H glutamate binding and Ca2+ activated neutral protease activity in rat hippocampal membranes. Fund Clin Pharmacol 1, 297, 1987 | Leggi il contenuto
The effect of calcium channel agonist BAY K-8644 on guinea-pig ileum and rat uterine horn. J Pharm Pharmacol 39, 954, 1987 | Leggi il contenuto
The action of taurine on chloride conductance and excitability characteristics of rat striated muscle fibers. Pharmacol Res Comm 19, 685, 1987 | Leggi il contenuto
Drug modulation of oxy-radical production by human neutrophyls. In: New Perspectives in Pharmacological Sciences. Eds. F. Drago and J.M. Van Ree, Published by The Italian Pharmacological Society, pp.  | Leggi il contenuto
D-arginine methylester activityon guinea-pig heart during hypoxia and reoxygenation. J Mol Cell Cardiol Supp 19, S-24, 1987 | Leggi il contenuto
Taurine reduces the increase in (Ca Ca2+)i due to phenylephrine in cardiac myocytes. Mol. Cell. Cardiol. 20 Supp. V, S-37, 1988 | Leggi il contenuto
Identification and characherization of polypeptides immunologicolhy related to cinguilin, a specifie protein component of tight junctions, in human epithelial cells. Pharmacol Res Comm 20 Supp 2, 374, | Leggi il contenuto
Studies on taurine positive inotropic effect in guinea-pig ventricular strips. Pharmacol Res Comm 20 Supp. I, 93, 1988 | Leggi il contenuto
Effect of I.C.V. taurine on the impairment of learning, convulsion and death caused by hypoxia. Psycopharmacol 98, 316, 1989 | Leggi il contenuto
Taurine's modulation of inotropism in guinea pig heart. Sulfur amino acids. In: Taurine and the heart. Iwata H, Lombardini JB, Segawa I, eds. Kluwer Acad. Press., 21, 1989 | Leggi il contenuto
The effect of taurine on pharmacologically induced myotonia. Muscle Nerve 12, 898, 1989 | Leggi il contenuto
Serum digoxin and Beta-methyldigoxin in elderly patients on hospital admission: correlation with home compliance and clinical variables. Eur J Clin Pharmacol.37, 401, 1989 | Leggi il contenuto
Effects of taurine on mammalian skeletal muscle fiber during development. Prog Clin Biol Res 351, 163-73, 1990 | Leggi il contenuto
Effect of taurine L-cysteic and orthanilic acids on cardiac tension. Prog Clin Biol Res 351, 175, 1990 | Leggi il contenuto
Carbon center radicals are involved in the regulation of L-type Ca2+ channels. Pharmacol Res 22: Supp 2, 217, 1990 | Leggi il contenuto
Effect of cumene-hyodroperoxide or hypoxia-reoxygenation on gluthatione status in guinea-pig heart. Biochem Pharmacol 39, 1617, 1990 | Leggi il contenuto
A cytotoxic effect of H2O2 trichomonas vaginalis may be correlated to cytoskleton modification. Pharmacol Res 22 Supp. 4 76, 1990 | Leggi il contenuto
Effect of non enzymatic radical generation on L-type calcium channel. Eur J Pharmacol 183, 1658, 1990 | Leggi il contenuto
Immuno quantitation of cytochrome c in cardiac perfusate J Immunoassay 12, 251, 1991 | Leggi il contenuto
Zampi GC: Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues. Am J Pathol. 138, 781, 1991 | Leggi il contenuto
Cardiac toxicology of cardiac depressant: principles of cardiotoxicology. Ed. S.I. Baskin, Telford Press Cadwell Boca Raton, p. 521, 1991 | Leggi il contenuto
Erythrocyte spermidine levels in IDDM patients Diabetes Cares, 15, 543, 1992 | Leggi il contenuto
Seghieri G: Taurine potentiates the antiaggregatory action of aspirin and indomethacin. In Taurine Nutritional Value and Mechanism of action Eds JB Lombardini, SW Schaffer, J Azuma, Plenum Press N.Y.  | Leggi il contenuto
Effects of taurine depletation on membrane electrical properties of rat skeletal muscle. In Taurine Nutritional Value and Mechanism of action. Eds. JB Lombardini, SW Schaffer, J Azuma, Plenum Press, 1 | Leggi il contenuto
Do ethoxy Radical Reduce 3H nitrendipine binding in rat cardiac membranes. Pharmacol Res Comm 26, 151, 1992 | Leggi il contenuto
Investigation on the antiproliferative activity of copper-cimetidine derivatives in neoplastic and syngeneic normal cells: role of H2-receptors. Ital J Biochem 41:,118A, 1992 | Leggi il contenuto
aB crystallin is not expressed in tumor cells derived from rat fibroblasts. Pharmacol Res 26: Suppl. 1, 67, 1992 | Leggi il contenuto
Taurine modifies platelet sensitivity to aspirin, indomethacin, sodium nitroprusside and papaverine. Platelets 3, 265, 1992 | Leggi il contenuto
Hydrogen peroxide-induced cytotoxicity in cultured epithelial cell (WISH): a functional and morphological study. Toxicol in Vitro 6, 533, 1992 | Leggi il contenuto
Taurine antagonizes the increase in intracellular calcium concentration induced by a-adrenergic stimulation in freshly isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol 24, 1253, 1992 | Leggi il contenuto
Plasma retinol and tocopherol concentrations in insulin-dependent diabetes mellitus: their relationship to microvascular complications. Internal J Vit Nutr Res 63, 87, 1993 | Leggi il contenuto
Release of cytochromes from hypoxic and reoxygenated guinea pig heart. Cardioscience 4, 177, 1993 | Leggi il contenuto
Plasma levels of retinol and of a-tocopherol in non-insulin dependent diabetes mellitus: its relation with micro- or macroangiopathy. Diab Nutr Metab 6, 207, 1993 | Leggi il contenuto
Enhancement of the antimicrobial activity of 5-nitroimidazole derivates by hydrogen peroxide. Microbiologica 16, 359, 1993 | Leggi il contenuto
Changes of the aB crystallin solubility properties in fibroblasts and sarcoma Galliera cells. It J Biochem 42, 284, 1993. | Leggi il contenuto
Renal excretion of ascorbic acid in insulin dependent diabetes mellitus. Internat J Vit Nutr Res 64,119, 1994 | Leggi il contenuto
Taurine level in plasma and platelets in insulin-dependent and non-insulin-dependent diabetes mellitus: correlation with platelet aggregation. In Taurine in Health and Diseases, eds, R.J. Huxtable, D. | Leggi il contenuto
Synthesis of antiplatelet activity of some 1,8-Naphthyridine derivates. Eur Med Chem 29, 735, 199 | Leggi il contenuto
Taurine levels in plasma and platelets in insulin-dependent diabetes mellitus: relationship with platelet aggregation. In Diabetes eds S. Baba, T. Kaneko, Elsevier, Amsterdam pag. 1087, 1995 | Leggi il contenuto
Glutathione, glutatione enzyme and thioltransferase in platelet of insulin-dependent diabetic patients: relation with aggregation and with microangiopathic complications. Eur J Clin Inv 25 | Leggi il contenuto
Taurine deficiency in plasma and platelets of diabetic insulin-dependent patients: effects of taurine supplementation. Am J Clin Nutr 61, 1115, 1995 | Leggi il contenuto
crystallin is constitutively expressed in cultures of bovine chondrocytes. Biochem Biophys Res Comm 208, 742, 1995. | Leggi il contenuto
Effect of taurine and hypotaurine on lipid peroxidation. Biochem Biophys Res Comm 213, 820, 1995 | Leggi il contenuto
Kinetic changes of ?B crystallin expression in neoplastic cells and in syngenic rat fibroblast at various subculture stage. Mol Cell Biochem 152, 23, 1995 | Leggi il contenuto
Serum Albumin Peroxidase activity in insulin dependent Diabetes Mellitus. Diabetes Nutr Met 8, 276, 1995 | Leggi il contenuto